Small Biotech Stories: American CryoStem

October 29, 2013 | Posted by Brianne Villano in Small Biotech Stories |


Some companies skirt regulations, opting instead to go off the radar. American CryoStem‘s Anthony Dudzinski‘s first words to me on the phone during our discussion were, “We follow the rules.” They’ve accumulated the greatest depth of adipose tissue-based cellular technology research relative to creating their laboratory and processes at a clinical cGMP level, and they’ve done it by actively engaging FDA consultants in the process.

Anthony F. Dudzinski, COO at American CryStem

Anthony F. Dudzinski, COO at American CryoStem

They’re looking at adipose-derived stem cells – also known as mesenchymal cells. ‘Mesenchymal’ was the original name of cells that came from bone marrow, and the two types are 98-99% identical, but there are some difference with the protein markers and capabilities of adipose vs. marrow cells.

Marrow cells are better for blood-borne diseases like lymphomas, whereas adipose-derived stem cells seems to be much more effective than marrow for structural issues. The concentration of adipose cells per gram of source material is actually 500-1000x greater than bone marrow from same patient. They have the ability to differentiate into a multitude of other cells including chondrocytes. This has incredible potential for how doctors treat sports injuries and aging issues.

Anthony set the stage for the importance of the research,”Most sports or age injuries are due to ligament or cartilage damage to the extent that most of them are bone on bone. So what if we could take Mrs. Smith who’s 55 and played tennis most of her life but can’t play anymore and doesn’t want to have knee replacement surgery. We can take cells out of the fat in her own body, attach them to a scaffold to induce chondrocytes, insert them into the meniscal cartilage area, and as time goes by with normal rehabilitation, her body regrows cartilage in her knees and her pain is gone.”

Anthony is excited about the implications for creating tissue for repairs, wound healing, burns, tendon injury, etc., all coming out of cells taken from adipose tissue. Read the rest of this entry »

Provider Best Practices: Completing Forms on Science Exchange

October 22, 2013 | Posted by Brianne Villano in Lab Admin Tools |

In order to successfully use Science Exchange, you have to fully understand how the site works. There are several times in which you’ll have to confirm a choice before submitting and moving on to the next task.

I’ll go over the following examples in this post:

Reproducibility Initiative receives $1.3M grant to validate 50 landmark cancer studies

October 16, 2013 | Posted by Elizabeth in Science Exchange News |


Over a year ago, I began my mission to improve scientific reproducibility. I created the Reproducibility Initiative with PLOS, figshare, and Mendeley to provide a mechanism for scientists to independently replicate findings and be rewarded for doing so. We have made great strides in our effort such as the validation of more than 1000 antibodies for antibodies-online. However, today is the day that I have made progress very near and dear to my heart. The Reproducibility Initiative has received a $1.3 million grant from the Laura and John Arnold Foundation to validate 50 landmark cancer biology studies.

Read the rest of this entry »

Provider Best Practices: 5 Ways To Rank Higher in Science Exchange Search Result

October 14, 2013 | Posted by Brianne Villano in Lab Admin Tools |

One of the best questions I get as the provider support manager is, “How do I rank higher in search results?!” This is a great question whose answer has many parts.

Here are five ways to rank higher in Science Exchange search:

1. Complete projects on Science Exchange!

  • I know this sounds circular, but hear me out. We have many providers on the site right now who got their first completed project by inviting existing clients onto Science Exchange. They use their facility page as their own scientific storefront and use the integrated project management tools to manage their internal and external workflow.

Scientist Spotlight: Gayathri Gopalakrishnan from the Space Science Institute

October 11, 2013 | Posted by Tess Mayall in Scientist Spotlight |
Gayathri Gopalakrishnan

Gayathri Gopalakrishnan

I recently met with Gayathri Gopalakrishnan. She is a Research Scientist in the Environmental Program at The Space Science Institute, a half-virtual institute of researchers based in Boulder, Colorado but located nationally.

Gayathri is an unusual and enlightening mix of curious, creative, and proactive. It is these assets combined with the unique atmosphere at the Space Science Institute that make her research and results so powerful.”I like to have my fingers in multiple pipes. It’s more fun when you can play with things on a really tiny scale, translate lab experiments to the field and run simulations of whole systems,” said Gayathri. Read the rest of this entry »

Provider Best Practices: How to Have a Better User Experience with Science Exchange – Internet Browser Edition

October 3, 2013 | Posted by Brianne Villano in Lab Admin Tools |

We use computers for much of the work we do every day. They are the powerhouses that allow us to accomplish amazing feats of science and technology. So why then do we ignore the upkeep and maintenance that these brilliant machines require to continue to help us excel?

In recent weeks, our team has seen some errors related to image and attachment uploads. These errors can often result from the version of internet browser being used. So this post is a brief run-through of reasons to keep your browser updated, not just to better utilize the Science Exchange site, but also to have a better internet experience overall.

  • Older browsers don’t support newer versions of HTML and CSS, the languages in which websites show themselves to us, so updated browsers allow you to see and use the websites in their best form.
  • Newer browser versions are simply faster. If you’re trying to upload a photo or estimate to our site, view content to make a decision about an important project, or just to watch cat videos without having to buffer, an updated browser can get you your content quicker.
  • Here at Science Exchange our personal favorite browser is Chrome  – it’s likely going to be your fastest choice for a browser. Support for HTML5 is unmatched and can make your experience on any site you choose to view much snappier.
  • No matter the browser you choose, older versions are less stable and more prone to security issues, so make sure to keep it updated to the most recent version.

We use Science Exchange because it is powerful and revolutionary.

So are our computers. Let’s take care of them.

Read the rest of this entry »

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