Science Exchange will be reproducing studies for the Movember Foundation-PCF Scientific Reproducibility Initiative

October 28, 2014 | Posted by Elizabeth in Reproducibility |

pcf1

We are proud to announce today that we have partnered with the Prostate Cancer Foundation (PCF), with funding from the Movember Foundation, to reproduce findings that have implications for prostate cancer patients. We will be collaborating with PCF to identify faster, high-impact biomedical findings that that can improve early detection and new cures.

PCF’s Chief Science Officer, Dr. Soule stated “This first-in-field foundation initiative is all about getting the smart stuff to patients quicker. We will see an acceleration of progress due to the mobilization of resources against the robust findings.”

Our Software Engineer Michael Kompanets with his Movember mustache.

Our Software Engineer Michael Kompanets with last year’s Movember mustache.

Science Exchange has a been long-time fan and supporter of PCF and the Movember Foundation (see picture to the right), so we are thrilled to be working with them to incorporate replication studies into their funding strategy. We will be utilizing the best practices that we’ve established for our Reproducibility Project: Cancer Biology to enable confirmation of high potential exploratory research results. Our hope is that by identifying robust reproducible results, we can accelerate prostate cancer research.

“The Movember Foundation is committed to accelerating the translation of promising discoveries into new tests and treatments,” said Paul Villanti, Executive Director of Programs, Movember Foundation. “Through quicker validation of the science, and if the science is true, we can help find new cures and prevent prostate cancer in more men at a faster rate. The Movember Foundation is confident that this initiative will play an important role in supporting this goal.” Read the rest of this entry »

Can Registered Reports help diagnose a reproducibility crisis?

October 14, 2014 | Posted by Reproducibility Project Core Team in Reproducibility |

There has been growing concern in the scientific community over the last several years about a lack of reproducible results in the biomedical research community. Recently, two large pharmaceutical companies (Amgen and Bayer) announced that they could only reproduce a small fraction of published preclinical cancer biology studies. These results have shocked the scientific community, and have lead to calls mandating an overhaul of both funding and publishing practices to address the crisis. The NIH, as well as the journals Nature and Science, are all proposing strategies to help improve the research process.

However, a major question remains: Why weren’t these experiments reproducible? Valid arguments exist suggesting scientists are falling prey to poor experimental design, flawed statistical analysis, and/or biased data interpretation, all of which can prevent their results from being replicable. However, there are many innocuous reasons why a particular experiment might fail to replicate the original results, from errors or changes in the protocol, to a lack of expertise in performing a particular technique, to unknown factors that produce variability in results. Unfortunately, it’s hard to draw conclusions from the Amgen and Bayer studies because these companies made none of their data or methods public.

The birth of the Reproducibility Project: Cancer Biology

We believe that in order to really understand the crisis in reproducibility, including its prevalence, scope and underlying causes, we need a large dataset of actual replication experiments. These replications must be conducted in a rigorously empirical fashion, using detailed protocols as close to the original study as possible, and conducted by expert scientists trained in the original techniques. Most importantly, the details of these replication datasets must be freely available to everyone.

These criteria led us to create the Reproducibility Project: Cancer Biology (RP:CB), a large-scale initiative to systematically replicate key findings from 50 highly impactful recent papers in the field of cancer biology. The project is a partnership between Science Exchange (and our network of expert service providers) and the Center for Open Science, and is funded through a grant from the Arnold Foundation, as well as through donations from many generous vendors. The goal of the project is to clarify the variety of challenges that exist for reproducibility, and encourage discussion of data-driven solutions from researchers themselves, as well as for policy makers at funding, publishing, and government institutions. To that end, all our findings will be published by the open-access journal eLife. Additionally, all of the methods, data, and results of the replication studies to be available for anyone to review on the Open Science Framework. Read the rest of this entry »

Find relevant scientific articles quicker

October 8, 2014 | Posted by Tess Mayall in Helpful products |

Sparrho imageWhen I was in grad school, I was expected to track and know every new piece of research that related to Indian Monsoons. However, no one told me how to do that. I didn’t have the years of experience and I definitely didn’t have the time to sort through the endless new articles coming out on a regular basis. There is now a website called Sparrho that simplifies the overwhelming process of tracking scientific articles.

Sparrho compiles scientific sources to one place and brings the latest and most relevant scientific news (including papers, grants, and patents) to users. Most importantly, Sparrho learns. As you continue to use Sparrho, it will learn your preferences and needs so that you can spend more time reading relevant articles, rather than digging for them. Read the rest of this entry »

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