New on Science Exchange: VR Tech, Cancer Genetics, Stem Cell-based Organoids

October 26, 2017 | Posted by Team in Drug Discovery, Helpful products, New Innovations, Research |

Chandreyee Das, Ph.D. | Senior Content Manager, Science Exchange | www.scienceexchange.com

Nanome Virtual Reality

Virtual Reality Software: Explore biology at nanoscale

From “Fantastic Voyage” (1966) to “A Wind in the Door” (1973), fiction has adored the idea of exploring the body at cellular and molecular levels. Now, virtual reality (VR) software, combined with the computational power afforded by blockchain technology, makes such journeys possible.

For your next computer-aided drug discovery/development (CADD) project, especially if you are collaborating with researchers across multiple sites, try molecular visualization using VR technology — now available from Nanome through Science Exchange.

Visit the Nanome storefront to connect with their team!

 

Cancer Genetics: Connect patients to discoveries

It’s a great day for precision medicine, with the unveiling of the first global directory of patient-derived xenografts (PDX).

Despite the attention given to precision medicine, however, less than 5% of cancer patients are participating in clinical trials. In the discovery phases of R&D, obtaining biospecimens of specific genotypes is also a continuing challenge.

Oncologists on Science Exchange can now accelerate their research with Cancer Genetics, Inc., a global CRO with a history of thought leadership in precision medicine.

Start a project today with Cancer Genetics, Inc.

 

Stem Cell-based 3D Organoids: Predict Preclinical Efficacy and Toxicity

3Dnamics Organoid Hippocampus

Organoids, particularly brain organoids, have enabled breakthrough research in Alzheimer’s disease, glioblastoma, and even ZIKA virus-induced microcephaly. By using pluripotent stem cells as a source of the multiple cell types present in an organoid, preclinical researchers can recapitulate in vivo-like tissue architecture and cellular heterogeneity.

Many of these discoveries were made by the founders of 3Dnamics, a new service provider on the Science Exchange network. The 3Dnamics team was built by stem cell pioneers and neuroscientists at Johns Hopkins University School of Medicine. If you are in the process of developing a model system for your preclinical or discovery-phase research, take advantage of 3Dnamics’ expertise.

Visit the 3Dnamics storefront

 

Accelerating Innovation and Mitigating Risk in Outsourced R&D

October 25, 2017 | Posted by Team in Drug Discovery, Events, Outsourcing Best Practices, Science Exchange News, Workshops |

Science Exchange Summit 2017

by Elizabeth Iorns, Ph.D., CEO and Co-Founder, Science Exchange | www.scienceexchange.com

Science Exchange recently hosted a group of procurement executives from multiple industries for our 2017 Science Exchange Outsourced R&D Leadership Summit. During the informative and interactive sessions, we discussed both the challenges and opportunities that organizations are facing as they seek to effectively manage outsourced R&D services.

From presentations by procurement leaders from major pharmaceutical companies on how they’re structuring procurement to enable innovation, to insights on how Science Exchange is pioneering new ways to make it easier to access innovation from our service providers, one of the key themes of the day was the potential for the procurement function to empower scientists to achieve breakthrough discovery. Here are some of my notes around the theme of innovation:

  • Procurement leaders can drive innovation, with the right tools. A pharmaceutical company procurement leader responsible for driving innovation shared that, in less than six months of working with Science Exchange, they had been able to increase their use of new, niche service providers by 11%.
  • Innovation can be hampered by complex processes. Natalie Foote, our Director of Service Provider Operations, presented with two of our service providers — iSpecimen and LabNetwork, a WuXi AppTec company– about new technology integrations with our platform. These integrations allow Science Exchange users to access the iSpecimen and LabNetwork marketplaces through a seamless access point on our platform — no barriers to innovation!
  • Flexible, agile procurement support helps drive innovation. During a panel discussion that I moderated, procurement leaders from three global pharmaceutical companies examined the need to more flexible and agile when it comes to managing R&D requests, and supporting the R&D business through an end-to-end process. They also discussed how their organizations must strategically examine the best mix of internal and external capabilities, core strengths and capacity when it comes to maximizing R&D innovation.

Another theme that surfaced during the Summit was risk mitigation, including the need to better manage confidentiality, data security and intellectual property (IP), and how to prepare for business continuity — whether caused by security breaches or natural disasters. My notes on the theme of risk mitigation:

  • Proactively mitigate risk. During the panel discussion, procurement leaders talked about the need to move beyond a “paper exercise” for managing risk, to a more proactive and rigorous approach to protecting their companies from data and security breaches and business continuity issues. One panelist discussed the drive for holding the business accountable for third-party risk oversight on a global scale, to move beyond that “check the box” mentality.   
  • Balance risk and innovation opportunity. Another panelist emphasized how important it is to strike the delicate balance between managing risk and enabling innovation, to ensure that businesses are protected without slowing down or blocking important scientific discoveries.  
  • Ask the right questions to assess risk. Our Director of Contracts & Compliance, Andrew Gutierrez, highlighted the need to ask the right questions in developing contracts and programs that will protect a company’s confidentiality and IP.He also talked about the need to verify how your data is being protected by your partners to ensure compliance with global regulations.

The Science Exchange Summit gave our entire team an opportunity to deepen our understanding of the needs of global procurement leaders, and our attendees gained insights to bring back to their own organizations, and a network of experts to collaborate with in the future. I look forward to continuing these discussions with our customers so we can continue to learn from one another and accelerate scientific discovery!

Learn more about how Science Exchange can help you — request a demo today.

iSpecimen and Science Exchange Announce Technology Integration to Allow Instant Access to Human Biospecimens

October 24, 2017 | Posted by Team in Company, Press Release, Science Exchange News |

Scientists in search of human biospecimens can now search the iSpecimen Marketplace via Science Exchange as part of one seamless experience

LEXINGTON, Mass. and PALO ALTO, Calif.Oct. 24, 2017 /PRNewswire/ —iSpecimen and Science Exchange today announced a marketplace technology integration that will allow Science Exchange users to directly search for biospecimens available in the iSpecimen Marketplace via a single user interface.

Science Exchange is the world’s leading and most secure platform for outsourced research and development (R&D) services, and the iSpecimen Marketplace is the premier online platform instantly connecting life science researchers in need of human biospecimens with the healthcare organizations that have them. By integrating these two solutions, Science Exchange users will now have access in real time to more than 25 million banked and prospectively collected specimens, including biofluids, solid tissue, and cells, all available on the iSpecimen Marketplace.

“iSpecimen shares our commitment to accelerating breakthrough scientific discovery through innovative technology,” said Elizabeth Iorns, PhD, Founder and CEO, Science Exchange. “With the seamless integration of the iSpecimen Marketplace and Science Exchange platform, our users gain direct, on-demand access to millions of human biospecimens.”

While iSpecimen has been available through Science Exchange since 2014, the new integration minimizes the time and complexity involved with specimen procurement. Additionally, the legal and compliance infrastructure in place for Science Exchange users reduces the risks often associated with biospecimen procurement. In the iSpecimen Marketplace, researchers have instant access to compliance documentation on a per specimen basis, giving researchers assurance before obtaining specimens that their requested samples were ethically sourced with appropriate regulatory oversight.

“The drive towards precision medicine is advancing the pace of research and increasing the need for biospecimens and related services,” said Christopher Ianelli, MD, PhD, Founder and CEO, iSpecimen. “The integration of the iSpecimen Marketplace into the Science Exchange environment accelerates research by giving scientists broader access to specimens from within the world’s leading platform for outsourced scientific services. We are honored to be working with Science Exchange in this way.”

Researchers interested in iSpecimen and Science Exchange can learn more and see demonstrations this week at ProcureCon Pharma in Philadelphia, where both Ianelli and Iorns will be speaking as part of a plenary panel.

QB3 Signs Partnership with Science Exchange

October 23, 2017 | Posted by Team in Company, Press Release, Science Exchange News |

Qb3 Partners With Science ExchangeBay Area Life Science Hub Enables its Startups to Stay Lean with Science Exchange’s R&D Platform

PALO ALTO, CA, October 23, 2017Science Exchange, a platform for outsourced research and development (R&D) services, today announced a partnership with QB3, the University of California hub for innovation and entrepreneurship for life sciences.

Through an exclusive Science Exchange-QB3 marketplace, QB3-affiliated companies will now have access to a customized and secure marketplace where they can instantly order R&D services from a network of more than 2,500 qualified scientific service providers. Science Exchange’s scientific concierge staff also will offer support to QB3’s start-up companies in identifying innovative providers and ordering complex R&D services.

“Science Exchange will help accelerate our companies by giving them access to providers that are experienced with entrepreneurial research and that have already been reviewed and qualified,” said Ioana Aanei, Ph.D., Entrepreneurship Program Manager at QB3. “Many of our startups don’t have the resources to purchase their own capital equipment or do the necessary specialized scientific research in-house.”

“Science Exchange is committed to helping life science companies bring innovative, potentially life-saving products to market,” said Elizabeth Iorns, Ph.D., Founder & CEO of Science Exchange. “While QB3’s companies focus on discovery, we can help eliminate the barriers, including the time and expertise needed to research and qualify contract research organizations (CROs) and scientific service providers. We also help save time and money in contract negotiation, all while ensuring the protection of intellectual property.”

QB3 joins more than 30 enterprise clients and entrepreneurial incubators that are efficiently managing their outsourced R&D with Science Exchange-powered marketplaces.

About QB3

QB3 is the University of California’s hub for innovation and entrepreneurship in the life sciences. The institute supports UC researchers and empowers Bay Area entrepreneurs to launch startup companies and partner with industry. QB3 helps bio-entrepreneurs create hundreds of high-value jobs and bring more than $750 million into the Bay Area each year. With campus divisions at Berkeley, San Francisco, and Santa Cruz, QB3 is also affiliated with the San Francisco incubator [email protected] — home to more than 45 companies — and the seed-stage venture capital firm Mission Bay Capital. Visit us at http://qb3.org/.

 

Science Exchange Honored by Goldman Sachs for Entrepreneurship

October 19, 2017 | Posted by Team in Company, Events, Press Release, Science Exchange News |

Co-Founder and CEO Elizabeth Iorns Among 100 Most Intriguing Entrepreneurs at 2017 Builders + Innovators Summit

Palo Alto, CA – October 19, 2017 – Goldman Sachs (NYSE:GS) is recognizing Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange as one of the 100 Most Intriguing Entrepreneurs of 2017 at its Builders + Innovators Summit in Santa Barbara, California.

Goldman Sachs selected Elizabeth as one of 100 entrepreneurs from multiple industries to be honored at the two-day event.

The life sciences research community has been transformed by Elizabeth’s ability to execute upon her vision to transform the procurement and delivery of outsourced R&D services. Thanks to her tenacity and drive, and her deep understanding of the need for improved R&D efficiency, Science Exchange is enabling breakthrough scientific discoveries by providing researchers with an online platform for efficient access to the world’s best outsourced R&D service providers.

“This is a tremendous honor and I’m excited to be recognized by Goldman Sachs along with these other inspiring entrepreneurs,” said Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange.  “The work our team at Science Exchange has been doing in outsourced R&D is critical for driving scientific breakthroughs and innovation and I’m proud to lead the team in this charge.”

“We are pleased to recognize Elizabeth Iorns as one of the most intriguing entrepreneurs of 2017,” said David M. Solomon, President and Co-Chief Operating Officer at Goldman Sachs. “This is the sixth year that we’ve hosted the Builders + Innovators Summit where emerging business leaders gather to discuss their common interests in building prosperous organizations.”

For more than 145 years, Goldman Sachs has been advising and financing entrepreneurs as they launch and grow their businesses. In addition to honoring 100 entrepreneurs, the Summit consists of general sessions and clinics led by Goldman Sachs experts, seasoned entrepreneurs, academics and business leaders as well as resident scholars.

About Elizabeth Iorns

Elizabeth Iorns, Ph.D., is the CEO and Founder of Science Exchange. Elizabeth Iorns has transformed scientific research by radically improving the procurement and delivery of outsourced research and development (R&D) services. Elizabeth Iorns, Ph.D. (Institute of Cancer Research, London) was an Assistant Professor at University of Miami’s Miller School of Medicine, where she investigated breast cancer development and progression, before launching Science Exchange in 2011. Elizabeth’s work has been featured in multiple media outlets, and she regularly speaks at thought leadership events, such as the 2017 TechCrunch Disrupt event in San Francisco, 2017 Society for Laboratory Automation and Screening annual meeting and the 2016 MassBio CRO/CMO Symposium. Her recent honors include Nature’s “Ten People that Mattered,” WIRED’s “50 Women Who Are Changing The World,” and the “Kauffman Foundation Emerging Entrepreneur Award.” She is a finalist for 2017 Scrip Executive of the Year Award.

About Science Exchange
Science Exchange is the world’s leading and most secure platform for outsourced research, providing an efficient procure-to-pay platform for ordering 6,000+ services from a network of more than 2,500 qualified scientific service providers, all with pre-established contracts in place that protect client intellectual property and confidentiality. The platform increases access to innovation and improves productivity, freeing scientists from administrative tasks and delays associated with sourcing, establishing and managing service provider contracts. Additionally, the Science Exchange enterprise program enables large R&D organizations to consolidate research outsourcing spend into a single strategic relationship, driving efficiency, improving transparency and oversight, and delivering cost savings. Since being founded in 2011, Science Exchange has raised more than $58 million from Norwest Venture Partners, Maverick Capital Ventures, Union Square Ventures, Collaborative Fund, Index Ventures, OATV, the YC Continuity Fund, and others. For more information, visit www.ScienceExchange.com. Follow the company on Twitter @ScienceExchange.

Service Provider Qualification and Monitoring Processes at Science Exchange

October 9, 2017 | Posted by Team in Company, Outsourcing Best Practices |

R&D organizations are rightfully cautious when selecting service providers. So much is at stake — reputation, intellectual property, pipeline decisions, regulatory approval, financial investments, and time. ISO 9001 Certified QMS Science Exchange

By partnering with Science Exchange, R&D organizations can finally rest assured that they are accessing a network of service providers that meets their most stringent criteria for quality and integrity.

Put your reputation into the best hands.

Every service provider on the Science Exchange platform is rigorously qualified and operates under pre-established legal agreements that protect intellectual property (IP), define confidentiality obligations, and ensure quality and compliance.

We stand by the unmatched quality of our ISO 9001-certified service provider qualification and monitoring processes. Our process verifies details of service provider compliance, reputation, financial standing, and staff expertise:

Provider Qualification & Monitoring Criteria  

Compliance Reputation Financials Expertise & Resources
  • Basic info (contact, billing, shipping)
  • Proof of certifications
  • FDA warning letters
  • USDA violations
  • Anti-bribery/Anti-corruption*
  • Social media
  • Client referrals
  • BBB complaints
  • Website verification
  • Facility/operations photos
  • Tax documents
  • Financial standing
  • Risk assessment
  • Employee headcount
  • Staff bios
  • Instrumentation
  • Detailed service descriptions
  • Validation data
  • Publications/patents

We require submission of compliance and capabilities information to help our clients determine whether the provider is the best fit for a proposed study. Information is either incorporated into the Science Exchange storefront for each facility or is stored within Science Exchange’s database. *Science Exchange checks against FPAC enforcement actions for anti-bribery/anti-corruption compliance.

Request a demo to see how our service provider quality management system protects our partner R&D organizations.

New on Science Exchange: Focus on Spectrometry

October 4, 2017 | Posted by Team in New Innovations, Research |

Chandreyee Das, Ph.D. | Senior Content Manager, Science Exchange | www.scienceexchange.com

This installment of New on Science Exchange features spectrometry experts at CMP Scientific, Protypia, CovalX, Nightingale Health, and The Scripps Center for Metabolomics. Ready.. set … analyze.

Emass-II Ion Source CMP Scientific

CMP Scientific: Capillary electrophoresis – mass spectrometry (CE-MS) experts

Analytical researchers frustrated by the long separation times, high sample requirements, or low throughput of LC-MS have long been attracted to the advantages of CE-MS.

In 2015, the CE-MS technique was revolutionized — in that year, Brooklyn, New York-based CMP Scientific pioneered the EMASS-II CE-MS ion source, a novel interface between the capillary and the mass spectrometer’s electrospray emitter that conferred nanoflow sensitivity and high electrospray efficiency.

Since then, CMP Scientific has gained a proven track record for helping drug discovery and development companies develop CE-MS methods for pharmaceutical and biopharmaceutical analysis. Will your research program be the next to benefit from CE-MS technology?

Connect with the CMP Scientific team on Science Exchange.

 

The Scripps Center for Metabolomics: Respected mass spec core exposes the exposome

What are the biological effects of the exposome — i.e., the sum of all environmental toxicants, food contaminants and supplements, drugs, and antibiotics your body is exposed to daily?

Thanks to XCMS/METLIN, a software combined with a cloud-based database founded by the researchers at the Scripps Center for Mass Spectrometry and Metabolomics, investigations into the elusive exposome are now possible. On September 25, the lab published the results of their initial study — and we were very excited to have such a groundbreaking team join the Science Exchange network!

The facility serves its customers both at Scripps Research Institute as well as in the broader biotechnology community with its analytical expertise, for routine as well as specialty projects. They offer not only ESI, MALDI, and GC/MS of a wide range of samples and analytes, but also access to the world’s leading metabolomics/lipidomics platform.

 

Nightingale Health: Epidemiology-scale metabolomics, using NMR

Based in Helsinki, Finland, Nightingale Health has been transforming population health studies using its novel, NMR spectroscopy-based platform to detect multiple metabolites, across diverse pathways, in human plasma and serum. This fully automated biomarker quantification method can provide superior repeatability compared to mass spectrometry methods and is coupled with automated quality control.

Now available on Science Exchange, Nightingale Health’s services are accessible to researchers seeking novel biomarkers for large population studies of cardiovascular health, diabetes, and other aspects of metabolic syndrome.

 

Protypia: Advancing immunooncology through quantitative proteomics

The complexity of immune checkpoint signaling has led the field to the conclusion that there are more determinants to immunotherapeutic efficacy than PD-1 or PD-L1 expression alone. Vanderbilt University’s Daniel Liebler, President and Founder of Protypia, has used his team’s expertise in quantitative proteomics to show that differential glycation of checkpoint signaling proteins could affect tissue staining results as well as signaling protein function [abstract].

Visit the Protypia storefront to request a quote for your proteomics project — this team might just enable your next drug discovery breakthrough.

 

CovalX: High-Mass MALDI yields cost-effective info on epitopes

Founded in 2005, this global, fast-growing service provider established its prominence by developing a very differentiated technology  — fast, sensitive and accurate analysis of protein complexes by High-Mass MALDI mass spectrometry. Unfragmented and undigested, the protein complexes are detected intact using specially developed cross-linking reagents and high-mass detection system.

Combined with CovalX’s covalent crosslinking technology, this mass spectrometry method provides a method for epitope mapping that is faster and more cost-effective than many other conformational analysis techniques. For researchers analyzing protein biotherapeutics and biosimilars, it’s an attractive option.

 

Browse these and other new service providers on Science Exchange today!

 

Easing the Bioinformatics Bottleneck: OnRamp Bioinformatics

October 4, 2017 | Posted by Team in Helpful products, Lab Profiles, New Innovations, Research, Uncategorized |

By Natalie Foote, Director of Service Provider Operations, Science Exchange | www.scienceexchange.comOnRamp Bio Logo

According to Tim Wesselman, CEO of today’s featured provider OnRamp Bioinformatics, there are only 15,000 bioinformaticians worldwide today to support more than 2 million biologists and other researchers. As a result, analysis has become the rate-limiting step in next-generation sequencing studies, and very large datasets may go un-analyzed to the point of obsoletion.

To ease this bottleneck, OnRamp Bio offers services that empower researchers with insights that they can understand and put into action.

Software as a service: accessible bioinformatics for non-experts

OnRamp Bio has made significant progress in making bioinformatics accessible to larger numbers of researchers. Earlier this year, OnRamp Bio launched a new software-as-a-service for RNA-Seq analysis, to meet the needs of researchers needing assistance in making decisions based on the large data sets yielded by RNA-Seq experiments.

Genomics big data and complex software analyses have historically required highly trained PhDs in Bioinformatics using complicated command-line tools. OnRamp Bio’s intuitive user interface, automated analyses and robust data management make it faster and easier for scientists, biologists, clinicians and other medical professionals to obtain interpretations of genomic data without the complexity of traditional deployments.

“IT complexity has stood in the way of progress for far too long. We’ve combined our deep knowledge of IT and biology to provide intuitive, integrated systems and services that accelerate mainstream adoption of NGS analyses within biotech and pharma,” said Tim Wesselman, CEO of OnRamp Bio. “For institutions focused on drug discovery, cancer research, diagnostic, or therapeutic development, OnRamp Bio can help show how to implement next generation sequencing to securely build into future research, while getting immediate answers more cost-efficiently.”

In addition to offering end-to-end genomic analysis services, OnRamp Bio recently made the news when it launched Rosalind™, the first-ever software platform specifically designed to simplify genomic analysis (named for one of the researchers who discovered the double helix structure of DNA).

Faces of OnRamp Bioinformatics

Jeremy Davis-Turak OnRamp BioJeremy Davis-Turak, VP of Bioinformatics, earned his Ph.D. in Bioinformatics and Systems Biology in the lab of Dr. Alexander Hoffmann at UCSD, researching kinetic models of co-transcriptional splicing.  In his studies, Dr. Davis-Turak developed analyses for RNA-seq, nascent RNA-seq, GRO-seq and MNase-seq that were intimately linked with mechanistic models.  He set up the Bioinformatics Core at the San Diego Center for Systems Biology, optimizing pipeline for RNA-seq and ChIP-seq.  

 

Jean Lozach OnRamp BioJean Lozach, Chief Technology Officer, joined OnRamp Bio after more than 25 years experience in Genomics, Bioinformatics and Information Technology at Illumina and UCSD. Jean brought deep experience and knowledge of biology, wet lab operations, microarrays, and next generation sequencing together with advanced bioinformatics, software development and enterprise IT infrastructure. Jean is recognized as an industry expert in genomics and bioinformatics, and has led tens of successful customer deployments of next generation sequencing and informatics systems.

Roshni Patel OnRamp BioRoshni Patel, Bioinformatician, has helped complete many projects for OnRamp Bio’s clients. She earned her BS of Bioinformatics from the University of California at San Diego, and she is passionate about breaking down workflow complexity, improving data metrics and visualization.

 

 

What Science Exchange Requesters are saying about OnRamp Bioinformatics

OnRamp Bio’s storefront shows several testimonials from Science Exchange requesters. One review, in particular, applauds both the breadth and quality of their services: “I highly recommend OnRamp for their Bioinformatics expertise. I have worked with them on several genomics and metagenomics projects and the team is professional, completes the work on deadline and budget, and generated results we hadn’t expected. OnRamp will work with you every step of the way, from project inception, through interfacing with sequencing partners, through developing novel informatics solutions for your project. OnRamp’s bioinformatics platform has many unique attributes that make it appealing, but their data and analysis tracking is just amazing: provenance for all your analyses from the minute the sequences arrive.”

 

Visit the OnRamp Bio storefront today to request some quotes!

 

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