Scientific research is advancing without pause; innovations are emerging at a breathtaking rate all over the world through the endeavors of diverse scientific disciplines. The future of scientific research is set on an unpredictable course teeming with both excitement and unease — whether AI-enabled tools will reshape drug discovery or if “patient-on-a-chip” technology will let future scientists create custom therapies for patients on the spot remains to be seen. Amidst the uncertainty, one thing remains clear: Science Exchange will be your fastest path to accessing new and emerging research tools, technologies, and services as the future continues to unfold.
A moment’s time is all you need to learn about the benefits of five promising technologies that may play an integral role in the near future. Sit back and Take 5! If something grabs your interest, click on the provided link to learn more about each service.
These novel affinity reagents, sometimes called “plastic antibodies,” have similar specificity to antibodies and can replace antibodies in in vitro applications, including sensing, imaging, purification, analysis, and diagnostics.
NanoMIPs are nanostructured Molecularly Imprinted Polymers, which typically contain a single binding site to a template molecule. NanoMIPs are prepared via a proprietary imprinting process that involves the self-assembly of binding monomers around a target template—these monomers are then polymerized to generate a “synthetic receptor” with high affinity and specificity to the template.
This next-generation chemical modification platform provides a superior alternative to CRISPR, siRNA, and shRNA approaches, and can be used to silence or regulate different RNA modalities.
Unlike conventional technologies, FANAs have high fidelity for the RNA target and highly reduced off-target effects (no RISC-associated off-target effects). These attributes represent a more potent, efficient, and cost-effective solution for RNA silencing and regulation.
This translational intestinal screening multi-well platform simulates the human colonic microbiota conditions in vitro and helps identify the pharmacological compounds metabolized by intestinal microbiota.
The Netherlands Organization (TNO)’s i-screen service enables rapid identification of drugs that are susceptible to metabolism by intestinal microbiota. Additionally, it can be used to identify unknown metabolites transformed by intestinal microbiota.
This service enables comprehensive profiling of up to 800 total and phosphoproteins from cell and tissue samples, using just 20–60 μg of protein.
Unlike other protein-profiling technologies, DigiWest allows in-depth analyses of cell signaling pathways on the level of phosphorylated proteins. As such, DigiWest adds significant value to biomarker identification, precision medicine, compound characterization, and mode-of-action studies.
This unique service is based on a patent-pending biological clearing agent called Visikol™ that penetrates tissue and renders it transparent without causing structural damage.
The assay has applications in the fields of toxicology, preclinical drug development, clinical diagnostics, basic research and plant biology, as tissues can be easily visualized in 3 dimensions.
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