PEAKS AB: The Fastest Path to Accurate Antibody Sequences
What challenges do you face in characterizing monoclonal antibodies (mAbs) at the molecular level? Whether it’s heterogeneity caused by truncation or glycation, or confounding isobaric amino acids, you’ve wished there was a better way.
You will learn about:
- Intact mass analysis of antibody proteins; why is it important?
- De novo antibody protein sequencing workflow used in PEAKS AB service: algorithm and experimental procedure
- Isoleucine and leucine differentiation by using EThcD fragmentation methods
About Our Speaker
Wen Zhang, Ph.D. is the Senior Application Scientist at Bioinformatics Solutions Inc. (BSI). With her rich experience in proteomics and MS data generation, processing and analysis, she joined BSI, where she now leads the antibody protein de novo sequencing projects. Her work includes intact mass, de novo sequencing, peptide mapping, post-translational modification, disulfide bond and N-linked glycan analyses.