We’re ready for the Charles River’s 23rd Annual Biotech Symposium!

July 26, 2017 | Posted by Team in Conferences, Events, New Innovations, Workshops |

by Annie Chen, Event Marketing Specialist, Science Exchange | www.scienceexchange.com

We are excited to attend the 23rd Annual Biotech Symposium hosted by Charles River, a leading service provider on the Science Exchange network — and we hope to see you there! Join your colleagues and industry experts from Bluebird, Janssen, Pfizer, and Amgen in Carlsbad, CA September 11–13.

With five different session tracks, join Charles River to learn about:

  • Biotherapeutic development programs and related case studies
  • Biomolecules and modifications to prolong a molecule’s half-life
  • Preclinical development of inhaled therapeutics
  • Microphysiology systems for biotherapeutics

Arrive one day early and attend the pre-symposium workshop titled, Where Does My Protein Go and Why Does It Matter? The Role of PK/PD in Biotherapeutics on Sunday, September 10.

Discounted room rates are available until August 11 and special registration fees are available to SOT BTSS members.

Register Now!

Service Providers Aim for Cancer Moonshot at AACR 2017

April 7, 2017 | Posted by Diana Truong in Conferences, Drug Discovery, Events, Helpful products, New Innovations, Research |

Greetings from the AACR Annual Meeting!

This year, we heard Joe Biden’s report on the progress of the Beau Biden Cancer Moonshot Initiative, compared immuno-oncology combination therapies, and mulled over the use of CRISPR screening to finding epigenetically controlled loci.

Joe Biden delivers the Cancer Moonshot Initiative update at AACR 2017

We also checked out the groundbreaking research being done by service providers on the Science Exchange network. Their work directly addresses the recommendations made last fall by the Moonshot’s Blue Ribbon Panel, and we are excited to give cancer researchers rapid access to these technologies through the Science Exchange platform!

Here are a few highlights from our exploration of #AACR17:

First humanized mouse model of tumor growth in bone: Pharmatest and Taconic Biosciences

The Moonshot Initiative’s recommendations specifically called out the potential of humanized mouse models to recapitulate the cellular architecture and heterogeneity found in human tumors. Traditional preclinical models that lack functional interactions between tumor, immune system and microenvironment have not been effective at predicting safety and efficacy of immunomodulating cancer drugs.

Taconic Biosciences showcases its novel animal models at AACR 2017

Pharmatest Services, Ltd. and Taconic Biosciences, both leaders in the development of predictive animal models, presented a poster at AACR 2017 showing the proliferation of human breast cancer cells in the bone injection site of humanized mice. The observed tumor growth, bone remodeling, and infiltration by human immune cells were similar to that seen in human breast cancer patients suffering from bone metastases.

Validation of this mouse model would be a very promising development for preclinical testing of immuno-oncology drug candidates and combination therapies.

 

Mass spectrometry imaging to characterize tumor microenvironment: Imabiotech

Imabiotech’s novel mass spectrometry imaging technology provides better toxicity and efficacy assessments in a number of therapeutic research areas, including immuno-oncology.

One challenge facing the Cancer Moonshot Initiative is that novel technologies are required to address tumor heterogeneity (at the cellular and molecular levels). Thus, the Blue Ribbon Panel called out multiplexed, quantitative imaging as a promising way to connect function with localization.

Imabiotech Corporation is a widely-published expert in the emerging field of mass spectrometry imaging, which is a promising technology to address tumor heterogeneity. Their poster and exhibit at AACR 2017 showcased how mass spectrometry imaging could be used to quantitatively characterize responses to immunotherapy in the tumor microenvironment, with spatial resolution.


Toward 3D patient-derived models of breast cancer, lung cancer, and glioblastoma: KIYATEC, Inc.

Another of the most challenging aspects of oncology is the fact that each patient has a different response to a particular therapy. Recognizing this, the Moonshot Initiative’s recommendations included a call to establish patient-derived test models, such as organoids and xenografts, in which candidate drugs could be tested before treatment.

KIYATEC presents 3D cell-based models for drug response profiling at AACR 2017

KIYATEC, whose expertise lies in generating and using 3D cell-based models for drug response profiling, presented their work on breast cancer, lung cancer, and glioblastoma multiforme (GBM), in three posters at AACR 2017.

One study addressed the challenges facing small cell lung cancer (SCLC) patients, for whom surgical resection is rarely feasible. Therefore, patient-derived tissue is difficult to obtain. KIYATEC was able to isolate functional cancer stem cells and circulating tumor cells, label-free, from SCLC patients, with the aim of developing 3D microtumors from these cells.

KIYATEC also showed that 3D models of breast cancer, which incorporated multiple stromal cell types and immune cells, responded differently to immune checkpoint inhibitors than standard 2D cell culture models. Finally, KIYATEC tackled GBM, for which therapy is particularly confounded by intra-tumor and inter-patient heterogeneity. They developed an efficient method to develop patient-derived 3D models, which may enable more personalized treatments for GBM.

Interested in working with these service providers? Order services on Science Exchange today, or contact us about your project.

Dan Knox, Co-Founder And COO Will Be Speaking At LabLaunch in Monrovia, CA

April 5, 2016 | Posted by Team in Company, Events |

Dan Knox, Co-Founder and COO, will be speaking at LabLaunch in Monrovia, CA, about how to use Science Exchange to order experiments from the world’s best labs. This event is part of the “Biotalk” seminar series which is a monthly educational networking event to support the current and potential biotech entrepreneurs of Los Angeles.
Agendadan
6:00pm-Networking and Refreshments
6:30pm-Presentation
When
Thursday, April 14, 2016 from 6:00 PM to 7:30 PM (PDT)

Where
LabLaunch-Monrovia – 605 Huntington Drive #103, Monrovia, CA 91016

Register

Koliber Biosciences Is Using Science Exchange To Develop Their Probiotic

January 20, 2016 | Posted by Team in Conferences, Events, Small Biotech Stories |

At the Blue Sky Bio Competition held during the SynBioBeta SF 2015 meeting, three finalists presented their ideas to the conference audience. They each hoped to win the prize resources in order to get the boost they needed to bring their ideas to fruition. Science Exchange sponsored this event, and presented the winners with $100,000 in credits to be used on the Science ExchEwa-Lisange platform. In the end, the audience decided to divide the winnings among the three finalists. Ewa Lis, founder and CEO of Koliber Biosciences and one of the winners, presented her ideas about probiotics and depression.

Ewa hopes to tackle the problem of depression. They propose to develop a probiotic strain that will produce a serotonin precursor of tryptophan directly in the gut. A probiotic supplement, especially if available over the counter, is more likely to be accepted by the large population of people that currently avoid medical treatment. It solves the problem of tryptophan degradation in the stomach and doesn’t require long treatment.

The market need for new depression treatments is clear. Depression affects 350 million people worldwide and results in $30 billion of economic loss. Two thirds of people suffering from depression do not seek medical treatment despite the existence of treatments. Moreover many failed treatments are due to patients stopping the medication themselves, often due to side effects.

Ewa and her team will use Science Exchange to develop probiotics that will ameliorate the effects of depression. To develop the strains they will use information from whole genome sequencing, RNA sequencing and analytical chemistry, services readily available via Science Exchange. Combined with their expertise in strain engineering and machine learning, they will be able to leverage the Science Exchange services to accelerate their research.

Science Exchange has many labs that can help Ewa and her team. For DNA sequencing, labs like Macrogen, Laragen, Quick Biology, Affiliated Genetics, ACGT and Applied Biological Materials can perform the work. For RNA sequencing, there are over 60 labs that can help Koliber Biosciences. In addition to these services, Science Exchange has labs that specifically focus on gut microbial community studies such as Second Genome. Lastly, Science Exchange offers many, many labs that perform standard studies such as amino acid analysis and compound synthesis. Science Exchange is the right resource to help Koliber Biosciences get started.

 

Have an idea for a product or company? Enter your idea in the Blue Sky Bio Competition for a chance to win over $500K in prizes.

September 25, 2015 | Posted by Keith Osiewicz in Company, Events |

We at Science Exchange love new ideas, and so we are partnering with SynBioBeta to sponsor the SynBioBeta SF 2015-Blue Sky Bio Competition. If you have an idea for a product, project or new company, please enter the competition by submitting an application. You have a chance of winning $500K in prizes that will help you bring your idea to fruition. Please enter by 12:00 pm PST on October 2nd.Blue-Sky-Bio-Competition

This competition consists of two stages. In the first stage, the judges will review all of the entrants and winnow away the group to 3 finalists. These three finalists will then compete in the second stage of the competition which will take place live and on-stage during the SynBioBeta 2015 conference. You will have 6 minutes to present a PowerPoint presentation describing your idea. The audience will be the judges for this stage of the competition, and they will have 4 minutes to vote for the best idea. Results will be shown live on the stage screen and the 1st, 2nd & 3rd place winners will be displayed.

We are donating $100K in credits to be used on Science Exchange. With these credits the winner can choose from over 4,000 services from over 900 service providers. Our online marketplace enables you to choose your own service providers, or you can use our Concierge service where our friendly team helps you find the right service providers for your project.

The SynBioBeta SF 2015-Blue Sky Bio competition takes place in the in the Robertson Auditorium in the Mission Bay Conference Center on Wednesday, Nov. 4th, from 4:35 to 5:35. Learn more.

Trivia Night at Science Exchange

November 22, 2013 | Posted by Tess Mayall in Events |

 image

Last night, Bay Area biologists, physicists, engineers, and one geologist came together to answer the most pressing scientific questions.

Tesla_circa_1890    Things like (answers are below):

    What is the name of the band that sings Weird Science?

    What two categories did Marie Curie win her Nobel Prize in?   

    Who is in the image to the left?

We were thrilled with the level of knowledge and enthusiasm of the group –       we had no idea that there were such fearsome, science trivia-lites among         us!

A few highlights from the night:

  • Team Darwinners winning first place, after an epic music round naming every science song/artist known to man. Even Thomas Dolby!
  • CEO Elizabeth Iorns’ excited exclamation that Ernest Rutherford was a kiwi.
  • Team Pasteur’s many name changes: Team Pasteur => Pasteur’s Pasture => Pastry => Patrizzle earning them Microryza t-shirts.
  • Everyone learning they’re seasoning their food with halite.

A huge thanks to everyone that came, we’re looking forward to many more to come. Stay tuned!

Answers: Oingo Boingo, Physics and Chemistry, Nikola Tesla

About the author

Tess builds Science Exchange’s online and offline community of scientists and providers. She is a geologist by training, but considers herself a friend of scientists near and far.

 

 

SpaceX at Science Exchange: Dragons and Falcons and Grasshoppers, oh my!

September 19, 2013 | Posted by Team in Events |
Chris White answering questions at SpaceX.

Chris White answering questions at Science Exchange.

Last Thursday Chris White, Director of Business Development at SpaceX, came by the new Science Exchange office to quiz us on SpaceX trivia, give out some goodies, and, in general, blow our minds with all things SpaceX. We had a tremendous turnout and were thrilled that people were as excited to talk to Chris as we were.

The evening began with some trivia questions easy and hard, like “What year was SpaceX founded?” FYI it was founded in 2002. Next, we listened to some Johnny Cash, admired the Grasshopper “Ring of Fire,” and witnessed the majesty of SpaceX spacecraft in some short but sweet videos. Finally, Chris jumped into a candid and informative overview of SpaceX, DragonLab, and their revolutionary approach to commercialized microgravity experiments. We learned some about what makes SpaceX tick, how DragonLab is empowering scientists globally to do their own microgravity experiments, and what it’s like to sit down with Elon Musk.

All in all, we couldn’t have asked for a better night filled with insightful discussions, engaging info, and laughs all around. Thank you to Chris White and the team at SpaceX for making it happen!

– The Science Exchange Team

March Metrics! The First Annual World Championship for Scientific Impact

February 11, 2013 | Posted by Guest in Events |

mmlogo

This is a guest post by Llewellyn Cox, Program Administrator for Research at the USC School of Pharmacy, and Founder of Research2.0. (full bio below).

Competition is the fuel that drives innovation. Without competition to drive evolution in nature, species retreat into genetic cul-de-sacs, leaving them vulnerable to ecological shifts and invasive species. In business, a lack of competition causes organizations to become bloated, inefficient bureaucracies that suffer from increasingly diminished returns. Without competition, career progress is arbitrary and unsatisfying, and sport is merely exercise. Read the rest of this entry »

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