Tech Q&A with CARE Research

February 12, 2018 | Posted by Team in Drug Discovery, New Innovations, Research |


 

Chandreyee Das, PhD, of Science Exchange recently spoke with Rajan Bawa, PhD, of CARE Research LLC, a leading preclinical CRO combining quality service for clients with excellent quality of life for animals — even for challenging or complex projects.

CD: Rajan, you’ve been in the pharmaceutical and biotechnology industry for over 40 years, can you tell us your company’s story?

RB: Twenty years ago, I started this histopathology company, Colorado Histo-Prep. In 2010, we acquired one of our preclinical CRO clients, which was CARE Research, enabling us to provide a one-stop-shop for our clients in the preclinical space.

CD: What capabilities does CARE Research have that set the company apart from other preclinical CROs?

RB: One differentiator is our ability to start projects very swiftly, with quick IACUC approval. We have extensive technical and regulatory experience.

Also, our responsiveness to our sponsor needs, being proactive in providing ongoing progress reports — we don’t wait until things go wrong.

We’re relatively small — we have about 20 people — but that means that we have high-ranking people in our organization — say, VP of Toxicology, or IACUC chairs — actively involved in projects. In large preclinical CROs, very often, there’s a study director who sits in his office, doesn’t even make it to the lab until the sponsor comes to visit.

CD: What preclinical services do you offer that are differentiated from other service providers?

RB: One area of strength is in DART (Developmental and reproductive toxicology) studies and ocular studies. DART services are not often offered by small or medium CROs, because they lack the expertise to carry out these specialized studies.

Ocular studies are another of our core competencies — these are also complex studies, you really have to know what you’re doing.

CD: What type of certifications does CARE Research hold?

RB: That’s a great question. We are OLA certified, AAALAC accredited, and we are GLP. We’re inspected regularly by FDA and USDA.

CD: What types of clients do you serve?

RB: We have a mix of different sponsors. We have large pharma, small biomedical companies, university researchers, startup companies.

In addition to our flexibility and ability to respond quickly, we have the ability to do very complex projects, especially in the surgical and ocular area in contrast to other CROs who may stay away from complex studies.

CD: Finally, could you describe your experience with Science Exchange?

RB: Science Exchange allows us to widen our reach, and allows us to find clients we would not have found using our internal resources. Also, the project managers whom I’ve interacted with are very helpful and responsive, and easily available to answer any questions, provide clarifications, etc in a patient manner.

 

Request a quote from CARE Research and get on the fastest path to completing your preclinical studies.

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De Novo Antibody Sequencing with Isoleucine/Leucine Discrimination

February 9, 2018 | Posted by Team in Drug Discovery, New Innovations, Research |

A three-in-one solution for obtaining 100% accurate amino acid sequences for antibody proteins 
Innovation Highlight

 

Obtaining the sequence of monoclonal antibodies (mAbs) is crucial for the development of some novel biotherapeutics. However, the need to extensively characterize mAbs at the molecular level presents a unique challenge to drug developers and manufacturers. To address this difficulty, Bioinformatics Solutions, Inc. (BSI) has developed the proprietary de novo antibody protein sequencing technology, based on their PEAKS AB Software, to sequence antibodies

This de novo antibody sequencing service is a 3-in-1 solution for obtaining 100% accurate amino acid sequences for antibody proteins with unknown sequences. BSI combines state-of-the-art top-down and bottom-up mass spectrometry (MS) technologies to achieve high accuracy of the constructed sequence with amino acid-level confidence.

Discriminating isoleucine from leucine

The latest EThcD (electron-transfer/higher-energy collision dissociation) fragmentation scheme is incorporated into the bottom-up MS workflow. The rich MS/MS spectra derived from EThcD fragmentation not only improves the accuracy and sensitivity of de novo sequencing but also generates signature w-ion for direct discrimination of the isobaric amino acids, isoleucine, and leucine. In turn, from their bottom-up MS analysis, BSI derives the antibody protein sequences with isoleucine and leucine differentiation by the EThcD method.

Addressing antibody heterogeneity challenges

In addition, the top-down MS workflow focuses on the intact mass of light and heavy chains. This addresses the antibody heterogeneity issues such as C-terminal lysine truncation and glycan forms, which cannot be well answered by bottom-up methods. The top-down MS result can also further validate the bottom-up sequencing result.

By integrating bottom-up MS analysis with EThcD and top-down MS approaches, the de novo antibody sequencing with Ile/Leu differentiation service offered by BSI can guarantee 100% sequence accuracy.

Overall, the industry demands more extensive and accurate characterization of antibodies, and BSI strives to answer this call. With continuous improvement and optimization, BSI sets to provide the most robust next-generation protein sequencing. Learn more.

Novaseek Research Partners with Science Exchange to Broaden Access to Its CDNR Platform for Biomedical and Clinical Research

February 5, 2018 | Posted by Team in Drug Discovery, New Innovations, Press Release, Research |

 

PALO ALTO, Calif., DATE – Science Exchange, the world’s leading enterprise platform for outsourced research and development services and acquisition of human biospecimens, announced today its partnership with Novaseek Research Inc., a health information technology for life sciences company.

Now thousands of researchers using Science Exchange have on-demand access to Novaseek’s Clinical Data Network for Research (CDNR) platform to procure biospecimens, with patient consent and authorization, and associated real-world clinical data in pursuit of accelerating medical innovation. Researchers can utilize the CDNR platform in support of discovery, translational medicine, observational and clinical studies while Science Exchange manages the contracting process and tracks analytics to report performance and process improvement.

“Our CDNR platform can help accelerate the long and costly research process by precisely identifying patient populations with highly specific characteristics, starting early in the development process and continuing throughout,” said Andrei Soran, CEO of Novaseek Research. “Our partnership with Science Exchange enables clinical researchers to focus on getting medicines to market faster while Science Exchange provides operational and service support.”

“The fastest path to novel platforms like Novaseek’s CDNR via Science Exchange helps our leading biopharma clients to accelerate the drug development process and get important medicines to market quickly,” said Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange. “We are committed to including the best scientific providers on our platform, and Novaseek meets our stringent vetting criteria. By leveraging population analytics, they help streamline study design and free scientists to focus on innovation.”

About Novaseek

Novaseek Research, Inc. is a game-changing health IT for life sciences company that provides turn-key, dynamic access to real world clinical data and biospecimens from a network of healthcare organizations. We envision a world where a clear understanding of real-world patients is central to every stage of life sciences research and drug development. For more information, please visit  www.novaseekresearch.com.

About CDNR

Novaseek’s award-winning, novel, cloud platform, the Clinical Data Network for Research (CDNR), easily interfaces with hospital data sources in real time. The CDNR enables researchers to define patient cohorts through population analytics and to access consented biospecimens and clinical data to advance translational medicine, clinical development and observational studies. CDNR enables the fulfillment of complex requests, such as the collection of biospecimens and data before and after specific treatments, without burdening patients with extra blood draws or extensive medical questionnaires. This approach allows more hospitals and patients to participate in supporting biomedical research.

 

Talk to the Novaseek team today about your biospecimen and clinical data needs — visit their storefront and request a quote with your Scope of Work.

Rapid Novor Inc. Launches REmAb™ Antibody Protein Sequencing Services on Science Exchange

January 24, 2018 | Posted by Team in Drug Discovery, New Innovations, Press Release, Research |

PALO ALTO, CA, January 25, 2018 – Science Exchange, the world’s leading and most secure enterprise platform for outsourced research and development (R&D) services, announced a partnership with Rapid Novor Inc to offer its REmAb™ Antibody Protein Sequencing Services to scientists around the world using Science Exchange’s R&D platform.

Rapid Novor, Inc. is a Kitchener-Waterloo (Canada)-based CRO dedicated to the development of antibody protein sequencing technologies. The company’s mission is to advance life science research to better human health with next-generation protein sequencing. With the opening of its own state-of-the-art mass spectrometry lab in 2017, the team has successfully sequenced hundreds of monoclonal antibodies directly from the proteins and helped pharmaceutical companies in their antibody drug discovery.

“Our focus is on the development of antibody protein sequencing technologies, and we are the only team that has both a mass spectrometry lab and proprietary sequencing software platform,” said Mingjie Xie, Co-founder and CEO of Rapid Novor, Inc. “We are uniquely positioned to offer superior protein sequencing services to researchers worldwide. The partnership with Science Exchange will allow us to provide easy-to-access services to enterprise biopharma companies and offer them cutting-edge technologies in a seamless manner.”

“We are thrilled to partner with Rapid Novor Inc to make its REmAb™ Antibody Protein Sequencing Services available to scientists worldwide,” said Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange. “By partnering with the leading CROs in different research and technology sectors, we are bringing in the best and brightest service providers to our secure and readily available platform so that the scientists can focus on developing breakthrough discoveries. Having Rapid Novor Inc as part of our supplier portfolios is an example of our commitment to making it easy for researchers to access the world’s leading scientific service providers and most innovative scientific technologies.”

About Rapid Novor, Inc.

Rapid Novor, Inc. is the world’s leader in antibody protein sequencing technology. Specializing in the field of mass spectrometry-based proteomics, the team has developed the technology to directly sequence the antibody proteins without needs to access the cell line. As a University of Waterloo spin-off, the company is building its technology portfolios based on the twenty years of scientific research and inventions from Dr. Bin Ma, co-founder and chief scientist. The company’s REmAb™ antibody protein sequencing service has allowed the accurate sequencing of any given antibody proteins routinely. The company’s WILD™ service is the first commercially available service that can accurately distinguish the isomeric isoleucine and leucine using mass spectrometry. For more information, visit www.rapidnovor.com. Follow the company on Twitter @rapidnovor.

Nanome Partners with Science Exchange to Offer Virtual Reality Drug Design Tools and Blockchain Solutions to Scientists

January 18, 2018 | Posted by Team in Drug Discovery, New Innovations, Press Release |

Nanome Partners with Science Exchange

PALO ALTO, CA, January 18, 2018 Science Exchange, the world’s leading and most secure enterprise platform for outsourced research and development (R&D) services, announced a partnership with Nanome Inc. to offer scientists on-demand access to Nanome’s blockchain and virtual reality technology.

Nanome is a San Diego-based company whose mission is to democratize science through blockchain technology and virtual reality tools to aid in the progression of molecular precision and advancements in nanotechnology.

“We can revolutionize the way science is done through our virtual reality drug design tool, NanoPro, and the Matryx blockchain platform,” said Steve McCloskey, CEO and Founder of Nanome. “Historically, scientists have had problems with collaboration and efficiency in their research, so we are excited to partner with Science Exchange to accelerate scientific development across the world.”

“We are thrilled to welcome Nanome to Science Exchange’s platform of more than 2,500 qualified providers that allow researchers access to innovative scientific technologies and services to advance their discoveries,” said Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange. “Our global community of scientists can now instantly access Nanome’s virtual reality drug design and development tool to better visualize complex 3D data through immersive applications.”

About Nanome

Nanome primarily helps medicinal chemists and structural biologists understand complex molecular data through immersive and collaborative applications that facilitate faster pattern recognition, better molecular visualization, and a more efficient drug design and drug discovery process. The Matryx blockchain platform enables researchers to collaborate and share results while securing their intellectual property through the blockchain.

Take 5: January 2018

January 13, 2018 | Posted by Team in Drug Discovery, New Innovations, Research |

by Gursatya “Guru” Singh, Director of Scientific Content, Science Exchange

In 2017, we zealously scouted for innovative new technologies and external research partners that can help accelerate the speed of your R&D and take your science to market via the fastest path. Once identified, these resources are made accessible, hassle-free, through the Science Exchange Marketplace.

We remain steadfastly dedicated to this pursuit in 2018, so every month you will get a sneak peek of the five innovations from our recent marketplace additions that are worth your attention. Sit back and Take 5! If something grabs your interest, click on the provided link to learn more about each service.

 

TLA TECHNOLOGY FOR TARGETED NGS OF GENES THAT MATTER

This technology provides complete sequence information of genes, oncogenes in patients, and transgenes, integration sites and gene editing events in (CHO) cell lines and animal models.

By designing a primer pair specific for a locus of interest, TLA enables the amplification and sequencing of > 10,000s of basepairs of surrounding sequence information.

LEARN MORE

 

VariantFind multisite saturation mutagenesisVARIANTFIND™ (AKA MULTISITE SATURATION MUTAGENESIS)

This flexible and scalable PCR-based platform can create DNA libraries for any gene of interest.

The platform is not limited by target gene length or %GC composition and all variants are generated by using a targeted mutagenesis approach.

LEARN MORE

 

 

 

3D Drug ScreeningCOMPLEX 3D DRUG SCREENING

This technology involves patented microplates, in standard 384-well format, but with each well containing 150 individual microwells, in each of which can be grown a different 3D cell culture/spheroid.

This ultra-high-throughput platform improves data consistency and reduces the number of replicate plates required, saving time and money for the investigator.

LEARN MORE

 

Pathogen TestingXPLORE-NGS PATHOGEN TESTING SERVICE

This service can identify all the known pathogens including bacteria, viruses, and even fungi simultaneously in a single test using sequencing and genomic analysis approaches.

With genetic sequencing and advanced informatics, Xplore-NGS testing produces faster and more accurate results than culture-based methods and other molecular-based approaches.

LEARN MORE

 

 

Tissue Phantom DevelopmentTISSUE PHANTOM DEVELOPMENT

This technology uses hydrogel formulations to mimic properties of native tissue, such as fat, muscle, and skin. Resulting “phantoms” can be used to test medical devices and surgical tools.

Some of the diverse applications of tissue phantoms include skin substitutes for testing sutures, casts of major organs for surgical training, and arterial models of atherosclerosis and cardiovascular disease.

LEARN MORE

 

Request quotes for these innovative services today!

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Breakout Labs Partners with Science Exchange to Empower its Portfolio Companies with External Research Innovations

December 18, 2017 | Posted by Team in New Innovations, Press Release, Science Exchange News |

Breakout Labs Science Exchange

Palo Alto, CA – December 18, 2017 — Science Exchange, the world’s leading and most secure enterprise platform for outsourced research and development (R&D), today announced a strategic partnership with Breakout Labs, a fund within the Thiel Foundation that backs scientist-entrepreneurs working at the intersections of technology, biology, materials, and energy. The newly formed partnership allows for Breakout Labs to provide its portfolio companies’ scientists with on-demand access to a global network of research suppliers via the Science Exchange-powered private marketplace.

The private marketplace enables instant access to thousands of research tools, technologies, and services from over 2,500+ commercial CROs, academic labs, and government facilities under a single Science Exchange contract. Additionally, the platform users receive end-to-end PhD-level support from the Science Exchange staff scientists in identifying the best external innovations to expedite their R&D cycles.

“Our companies are small innovative startups that, despite being cash-constrained, are at the forefront of radical scientific breakthroughs,” said Hemai Parthasarathy, Scientific Director of Breakout Labs.  “Science Exchange’s marketplace helps these companies adopt virtualization in their R&D process and give them an opportunity to access external resources they need to bring their innovations to market. Science Exchange fits into the ethos that prompted the formation of Breakout Labs by removing barriers for startups to access scientific services that will help accelerate their discoveries.”

“At Science Exchange, we are passionate about accelerating discovery by making connections — in this case, vital connections between scientist-entrepreneurs and experienced providers of scientific products and services,” said Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange. “Through this partnership, the scientists at Breakout Labs’ companies, can now focus on what they do best, bringing game-changing scientific discoveries to market, and rely on us to find the best scientific providers to help them accomplish that.”

Breakout Labs is the latest R&D organization to choose to partner with Science Exchange and join more than 30 enterprise clients and Life Science incubators that are effectively managing their outsourced R&D with Science Exchange-powered marketplaces.

About Breakout Labs

Breakout Labs is a revolving fund within the Thiel Foundation that supports early stage companies as they transition radical scientific advances out of the research lab and into the economy. The program backs bold scientists who work at the intersections of technology, biology, materials, and energy. More than capital, Breakout Labs provides additional support through a two-year program that includes introductions to follow-on funders, corporate partners and other resources to drive commercialization. To learn more, visit: www.breakoutlabs.org.

New on Science Exchange: BiTE Screening for Immunooncology, Editing Primary Cells, and Advances in NGS

December 18, 2017 | Posted by Team in Drug Discovery, New Innovations, Research |

–Chandreyee Das, Ph.D. | Senior Content Manager, Science Exchange


Retrogenix BiTE Screening

Screening for immunotherapies: Take a BiTE out of cancer

Bispecific T-Cell Engager Antibodies, or “BiTE” antibodies, are thought to be safe and efficacious candidates for cancer immunotherapy.

But the specificity of membrane receptor binding is hard to characterize.

A unique new technology from Retrogenix has caught the attention of dozens of pharmaceutical companies in the immunooncology space — seeking to use Retrogenix services for discovering immune checkpoint modulators, perform CAR-T cell specificity screening, and more. It’s not surprising that the company was recognized by an award from the Queen of England!

Visit the Retrogenix storefront to connect with their team

 

Unlocking genomics: From tortoises to transcriptomes

In 2006, Fasteris became the first service provider to order an Illumina NGS instrument. This year, they celebrated 20 years of providing NGS services to the world, applying their expertise to diverse studies, ranging from transcriptomics to elucidate T-cell differentiation, microbiome metagenomics, herpes virus infection in wild frogs, and host-pathogen interactions in tortoises.

Earlier this year, the company collaborated on a project to sequence cell-free DNA from over 6,000 cases of fetal aneuploidy — using a novel method developed at Fasteris in 2013.

Start a project today with Fasteris

 

Gene editing in primary cells: Be on the (DNA-cutting) edgeB-Mogen Banner

Gene editing is hard enough — and it’s even harder in primary cells. A company that combines expertise in gene delivery AND gene editing has an advantage in this space — and that company is B-MoGen Biotechnologies, recent recipients of an NIH grant for developing novel genome editing technologies.

B-MoGen offers a proprietary technology for editing nearly any primary human cell type — CD34s, T cells, B cells, etc.

Gain the editing edge with the B-MoGen team

 

 

Bioinformatics Solutions, Inc. Chooses Science Exchange as the Primary Online Channel to Offer Protein de novo Sequencing Services to Scientists

December 11, 2017 | Posted by Team in Lab Profiles, New Innovations, Press Release, Research |

BSI Science Exchange Partnership

PALO ALTO, CA, December 11, 2017 – Science Exchange, the world’s leading and most secure enterprise platform for outsourced research and development (R&D) services, announced the partnership with Bioinformatics Solutions, Inc. to offer online access to its protein de novo sequencing services to scientists around the globe.

As the creators of the well-known, highly established PEAKS Software, the golden standard of de novo sequencing, Bioinformatics Solutions, Inc., offers their de novo sequencing expertise to scientists at a new level by sequencing the samples themselves.

“Bioinformatics Solutions, Inc. has developed a proprietary de novo protein sequencing workflow to retrieve the amino acid sequence of an unknown antibody protein with state-of-the-art mass spectrometry techniques. Through this workflow, the sequence assembly is purely based on de novo sequencing. Therefore, no database, cDNA, mRNA, or hybridoma cell line is required,” exclaims Baozhen Shan, CEO of Bioinformatics Solutions, Inc. “With constant ongoing research at Bioinformatics Solutions, Inc., the advanced technology will ensure our service delivers a highly accurate sequence, identification of sequence variants, glycosylations, and unknown modifications.  By partnering with Science Exchange, these sequencing services will now be available to researchers all over the world to help them make breakthrough discoveries.”

Over the last few years, Science Exchange has undergone extensive growth and recently received a $28 million in Series C funding led by Norwest Venture Partners. By continuing to team up with companies like Bioinformatics Solutions, Inc. Science Exchange is providing researchers worldwide with access to the most important scientific services to advance their experiments.

“We are excited to partner with Bioinformatics Solutions, Inc. to make available its protein de novo sequencing services to scientists worldwide,” said Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange.  “Science Exchange is committed to adding the most innovative and qualified service providers to our platform, so scientists have the services they need securely and readily available to aid their discoveries. Bioinformatics Solutions, Inc. met our rigorous standards for quality and compliance while demonstrating breakthrough discoveries in the field of proteomics analysis.”

 

About Bioinformatics Solutions, Inc.

For more than 15 years, Bioinformatics Solutions, Inc. has been changing the field of proteomics analysis, by pushing the boundaries of its computational limits and striving to provide groundbreaking research with the customer-first approach. Bioinformatics Solutions, Inc. believes the only solution is one that incorporates quality and timely results, a satisfying product experience, customer support and two-way communication. This diverse and adaptable group is committed to serving the needs of pharmaceutical, biotechnological, and academic scientists; and to the progression of recombinant protein production and drug discovery research. For more information, visit www.scienceexchange.com/labs/bioinformatics-solutions-inc. Follow the company on Twitter @PEAKSProteomics and @PEAKSAB.

Science Exchange Scientific Provider Elion Labs Presenting New Research at the AAPS Annual Meeting

November 13, 2017 | Posted by Team in Drug Discovery, Events, New Innovations, Press Release, Research |
  • Breakthrough in drug product particle analysis using machine learning

  • Biopharma researchers can access Elion’s new services from scienceexchange.com

Science Exchange and Elion at AAPS

PALO ALTO, CA, and LOUISVILLE, CO, November 13, 2017 Science Exchange, the world’s leading and most secure enterprise platform for outsourced research and development, is proud to announce that Elion Labs, provider of analytical development and drug product characterization services, will present exciting new research at the 2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting, the most comprehensive event for innovations in bioanalysis, formulation, and product characterization.

Elion’s expertise has helped bring numerous clinical products to market. Their AAPS research poster presentation (Abstract M8003) introduces a novel method for drug product analysis, using machine learning and advanced image analysis to improve particle detection, enumeration, and classification.

“Machine learning approaches open up exciting new possibilities for analyzing particles in biologics, and ultimately, for better analyzing a broad range of complex data sets,”  said John Gabrielson, Ph.D., CEO and Founding Partner of Elion Labs. “We hope that our research will help biopharmaceutical researchers develop safer, more effective drugs and deliver them to patients faster.”

Elion and Science Exchange will exhibit at booth 2337 at AAPS, meeting drug discovery and development researchers and representatives of regulatory agencies seeking the latest, innovative services available for pharmaceutical analysis.

“We’re proud to participate in this year’s conference alongside Elion, who are true thought leaders in analytical research,” said Elizabeth Iorns, Ph.D., CEO and Co-Founder of Science Exchange. “And because they’re part of the Science Exchange network, biopharmaceutical researchers can access Elion’s technologies immediately under our pre-existing master service agreement that covers IP and confidentiality.”

More information about Elion Labs and their innovative services can be found at www.scienceexchange.com/labs/elion-labs.

 

About Elion Labs

Elion Labs, based in Louisville, Colorado, USA, was founded to serve the analytical development and product characterization needs of the biopharmaceutical industry. Elion offers a variety of services, including analytical method development, qualification and validation; analytical characterization testing of biologics; formulation development; training in highly specialized analytical techniques; comprehensive data analysis including visualization and interpretation of complex data sets; technical and regulatory writing; and technical consulting. They are committed to providing all services with unmatched professionalism, quality, and speed.

About Science Exchange

Science Exchange is the world’s leading and most secure platform for outsourced research, providing an efficient procure-to-pay platform for ordering 6,000+ services from a network of more than 2,500 qualified scientific service providers, all with pre-established contracts in place that protect client intellectual property and confidentiality. The platform increases access to innovation and improves productivity, freeing scientists from administrative tasks and delays associated with sourcing, establishing and managing service provider contracts. Additionally, the Science Exchange enterprise program enables large R&D organizations to consolidate research outsourcing spend into a single strategic relationship, driving efficiency, improving transparency and oversight, and delivering cost savings. Since being founded in 2011, Science Exchange has raised more than $58 million from Norwest Venture Partners, Maverick Capital Ventures, Union Square Ventures, Collaborative Fund, Index Ventures, OATV, the YC Continuity Fund, and others. For more information, visit www.ScienceExchange.com. Follow the company on Twitter @ScienceExchange.

 

 

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