Bioinformatics Solutions, Inc. Chooses Science Exchange as the Primary Online Channel to Offer Protein de novo Sequencing Services to Scientists

December 11, 2017 | Posted by Team in Lab Profiles, New Innovations, Press Release, Research |

BSI Science Exchange Partnership

PALO ALTO, CA, December 11, 2017 – Science Exchange, the world’s leading and most secure enterprise platform for outsourced research and development (R&D) services, announced the partnership with Bioinformatics Solutions, Inc. to offer online access to its protein de novo sequencing services to scientists around the globe.

As the creators of the well-known, highly established PEAKS Software, the golden standard of de novo sequencing, Bioinformatics Solutions, Inc., offers their de novo sequencing expertise to scientists at a new level by sequencing the samples themselves.

“Bioinformatics Solutions, Inc. has developed a proprietary de novo protein sequencing workflow to retrieve the amino acid sequence of an unknown antibody protein with state-of-the-art mass spectrometry techniques. Through this workflow, the sequence assembly is purely based on de novo sequencing. Therefore, no database, cDNA, mRNA, or hybridoma cell line is required,” exclaims Baozhen Shan, CEO of Bioinformatics Solutions, Inc. “With constant ongoing research at Bioinformatics Solutions, Inc., the advanced technology will ensure our service delivers a highly accurate sequence, identification of sequence variants, glycosylations, and unknown modifications.  By partnering with Science Exchange, these sequencing services will now be available to researchers all over the world to help them make breakthrough discoveries.”

Over the last few years, Science Exchange has undergone extensive growth and recently received a $28 million in Series C funding led by Norwest Venture Partners. By continuing to team up with companies like Bioinformatics Solutions, Inc. Science Exchange is providing researchers worldwide with access to the most important scientific services to advance their experiments.

“We are excited to partner with Bioinformatics Solutions, Inc. to make available its protein de novo sequencing services to scientists worldwide,” said Elizabeth Iorns, Ph.D., co-founder and CEO of Science Exchange.  “Science Exchange is committed to adding the most innovative and qualified service providers to our platform, so scientists have the services they need securely and readily available to aid their discoveries. Bioinformatics Solutions, Inc. met our rigorous standards for quality and compliance while demonstrating breakthrough discoveries in the field of proteomics analysis.”

 

About Bioinformatics Solutions, Inc.

For more than 15 years, Bioinformatics Solutions, Inc. has been changing the field of proteomics analysis, by pushing the boundaries of its computational limits and striving to provide groundbreaking research with the customer-first approach. Bioinformatics Solutions, Inc. believes the only solution is one that incorporates quality and timely results, a satisfying product experience, customer support and two-way communication. This diverse and adaptable group is committed to serving the needs of pharmaceutical, biotechnological, and academic scientists; and to the progression of recombinant protein production and drug discovery research. For more information, visit www.scienceexchange.com/labs/bioinformatics-solutions-inc. Follow the company on Twitter @PEAKSProteomics and @PEAKSAB.

Science Exchange Scientific Provider Elion Labs Presenting New Research at the AAPS Annual Meeting

November 13, 2017 | Posted by Team in Drug Discovery, Events, New Innovations, Press Release, Research |
  • Breakthrough in drug product particle analysis using machine learning

  • Biopharma researchers can access Elion’s new services from scienceexchange.com

Science Exchange and Elion at AAPS

PALO ALTO, CA, and LOUISVILLE, CO, November 13, 2017 Science Exchange, the world’s leading and most secure enterprise platform for outsourced research and development, is proud to announce that Elion Labs, provider of analytical development and drug product characterization services, will present exciting new research at the 2017 AAPS (American Association of Pharmaceutical Scientists) Annual Meeting, the most comprehensive event for innovations in bioanalysis, formulation, and product characterization.

Elion’s expertise has helped bring numerous clinical products to market. Their AAPS research poster presentation (Abstract M8003) introduces a novel method for drug product analysis, using machine learning and advanced image analysis to improve particle detection, enumeration, and classification.

“Machine learning approaches open up exciting new possibilities for analyzing particles in biologics, and ultimately, for better analyzing a broad range of complex data sets,”  said John Gabrielson, Ph.D., CEO and Founding Partner of Elion Labs. “We hope that our research will help biopharmaceutical researchers develop safer, more effective drugs and deliver them to patients faster.”

Elion and Science Exchange will exhibit at booth 2337 at AAPS, meeting drug discovery and development researchers and representatives of regulatory agencies seeking the latest, innovative services available for pharmaceutical analysis.

“We’re proud to participate in this year’s conference alongside Elion, who are true thought leaders in analytical research,” said Elizabeth Iorns, Ph.D., CEO and Co-Founder of Science Exchange. “And because they’re part of the Science Exchange network, biopharmaceutical researchers can access Elion’s technologies immediately under our pre-existing master service agreement that covers IP and confidentiality.”

More information about Elion Labs and their innovative services can be found at www.scienceexchange.com/labs/elion-labs.

 

About Elion Labs

Elion Labs, based in Louisville, Colorado, USA, was founded to serve the analytical development and product characterization needs of the biopharmaceutical industry. Elion offers a variety of services, including analytical method development, qualification and validation; analytical characterization testing of biologics; formulation development; training in highly specialized analytical techniques; comprehensive data analysis including visualization and interpretation of complex data sets; technical and regulatory writing; and technical consulting. They are committed to providing all services with unmatched professionalism, quality, and speed.

About Science Exchange

Science Exchange is the world’s leading and most secure platform for outsourced research, providing an efficient procure-to-pay platform for ordering 6,000+ services from a network of more than 2,500 qualified scientific service providers, all with pre-established contracts in place that protect client intellectual property and confidentiality. The platform increases access to innovation and improves productivity, freeing scientists from administrative tasks and delays associated with sourcing, establishing and managing service provider contracts. Additionally, the Science Exchange enterprise program enables large R&D organizations to consolidate research outsourcing spend into a single strategic relationship, driving efficiency, improving transparency and oversight, and delivering cost savings. Since being founded in 2011, Science Exchange has raised more than $58 million from Norwest Venture Partners, Maverick Capital Ventures, Union Square Ventures, Collaborative Fund, Index Ventures, OATV, the YC Continuity Fund, and others. For more information, visit www.ScienceExchange.com. Follow the company on Twitter @ScienceExchange.

 

 

New on Science Exchange: VR Tech, Cancer Genetics, Stem Cell-based Organoids

October 26, 2017 | Posted by Team in Drug Discovery, Helpful products, New Innovations, Research |

Chandreyee Das, Ph.D. | Senior Content Manager, Science Exchange | www.scienceexchange.com

Nanome Virtual Reality

Virtual Reality Software: Explore biology at nanoscale

From “Fantastic Voyage” (1966) to “A Wind in the Door” (1973), fiction has adored the idea of exploring the body at cellular and molecular levels. Now, virtual reality (VR) software, combined with the computational power afforded by blockchain technology, makes such journeys possible.

For your next computer-aided drug discovery/development (CADD) project, especially if you are collaborating with researchers across multiple sites, try molecular visualization using VR technology — now available from Nanome through Science Exchange.

Visit the Nanome storefront to connect with their team!

 

Cancer Genetics: Connect patients to discoveries

It’s a great day for precision medicine, with the unveiling of the first global directory of patient-derived xenografts (PDX).

Despite the attention given to precision medicine, however, less than 5% of cancer patients are participating in clinical trials. In the discovery phases of R&D, obtaining biospecimens of specific genotypes is also a continuing challenge.

Oncologists on Science Exchange can now accelerate their research with Cancer Genetics, Inc., a global CRO with a history of thought leadership in precision medicine.

Start a project today with Cancer Genetics, Inc.

 

Stem Cell-based 3D Organoids: Predict Preclinical Efficacy and Toxicity

3Dnamics Organoid Hippocampus

Organoids, particularly brain organoids, have enabled breakthrough research in Alzheimer’s disease, glioblastoma, and even ZIKA virus-induced microcephaly. By using pluripotent stem cells as a source of the multiple cell types present in an organoid, preclinical researchers can recapitulate in vivo-like tissue architecture and cellular heterogeneity.

Many of these discoveries were made by the founders of 3Dnamics, a new service provider on the Science Exchange network. The 3Dnamics team was built by stem cell pioneers and neuroscientists at Johns Hopkins University School of Medicine. If you are in the process of developing a model system for your preclinical or discovery-phase research, take advantage of 3Dnamics’ expertise.

Visit the 3Dnamics storefront

 

New on Science Exchange: Focus on Spectrometry

October 4, 2017 | Posted by Team in New Innovations, Research |

Chandreyee Das, Ph.D. | Senior Content Manager, Science Exchange | www.scienceexchange.com

This installment of New on Science Exchange features spectrometry experts at CMP Scientific, Protypia, CovalX, Nightingale Health, and The Scripps Center for Metabolomics. Ready.. set … analyze.

Emass-II Ion Source CMP Scientific

CMP Scientific: Capillary electrophoresis – mass spectrometry (CE-MS) experts

Analytical researchers frustrated by the long separation times, high sample requirements, or low throughput of LC-MS have long been attracted to the advantages of CE-MS.

In 2015, the CE-MS technique was revolutionized — in that year, Brooklyn, New York-based CMP Scientific pioneered the EMASS-II CE-MS ion source, a novel interface between the capillary and the mass spectrometer’s electrospray emitter that conferred nanoflow sensitivity and high electrospray efficiency.

Since then, CMP Scientific has gained a proven track record for helping drug discovery and development companies develop CE-MS methods for pharmaceutical and biopharmaceutical analysis. Will your research program be the next to benefit from CE-MS technology?

Connect with the CMP Scientific team on Science Exchange.

 

The Scripps Center for Metabolomics: Respected mass spec core exposes the exposome

What are the biological effects of the exposome — i.e., the sum of all environmental toxicants, food contaminants and supplements, drugs, and antibiotics your body is exposed to daily?

Thanks to XCMS/METLIN, a software combined with a cloud-based database founded by the researchers at the Scripps Center for Mass Spectrometry and Metabolomics, investigations into the elusive exposome are now possible. On September 25, the lab published the results of their initial study — and we were very excited to have such a groundbreaking team join the Science Exchange network!

The facility serves its customers both at Scripps Research Institute as well as in the broader biotechnology community with its analytical expertise, for routine as well as specialty projects. They offer not only ESI, MALDI, and GC/MS of a wide range of samples and analytes, but also access to the world’s leading metabolomics/lipidomics platform.

 

Nightingale Health: Epidemiology-scale metabolomics, using NMR

Based in Helsinki, Finland, Nightingale Health has been transforming population health studies using its novel, NMR spectroscopy-based platform to detect multiple metabolites, across diverse pathways, in human plasma and serum. This fully automated biomarker quantification method can provide superior repeatability compared to mass spectrometry methods and is coupled with automated quality control.

Now available on Science Exchange, Nightingale Health’s services are accessible to researchers seeking novel biomarkers for large population studies of cardiovascular health, diabetes, and other aspects of metabolic syndrome.

 

Protypia: Advancing immunooncology through quantitative proteomics

The complexity of immune checkpoint signaling has led the field to the conclusion that there are more determinants to immunotherapeutic efficacy than PD-1 or PD-L1 expression alone. Vanderbilt University’s Daniel Liebler, President and Founder of Protypia, has used his team’s expertise in quantitative proteomics to show that differential glycation of checkpoint signaling proteins could affect tissue staining results as well as signaling protein function [abstract].

Visit the Protypia storefront to request a quote for your proteomics project — this team might just enable your next drug discovery breakthrough.

 

CovalX: High-Mass MALDI yields cost-effective info on epitopes

Founded in 2005, this global, fast-growing service provider established its prominence by developing a very differentiated technology  — fast, sensitive and accurate analysis of protein complexes by High-Mass MALDI mass spectrometry. Unfragmented and undigested, the protein complexes are detected intact using specially developed cross-linking reagents and high-mass detection system.

Combined with CovalX’s covalent crosslinking technology, this mass spectrometry method provides a method for epitope mapping that is faster and more cost-effective than many other conformational analysis techniques. For researchers analyzing protein biotherapeutics and biosimilars, it’s an attractive option.

 

Browse these and other new service providers on Science Exchange today!

 

Easing the Bioinformatics Bottleneck: OnRamp Bioinformatics

October 4, 2017 | Posted by Team in Helpful products, Lab Profiles, New Innovations, Research, Uncategorized |

By Natalie Foote, Director of Service Provider Operations, Science Exchange | www.scienceexchange.comOnRamp Bio Logo

According to Tim Wesselman, CEO of today’s featured provider OnRamp Bioinformatics, there are only 15,000 bioinformaticians worldwide today to support more than 2 million biologists and other researchers. As a result, analysis has become the rate-limiting step in next-generation sequencing studies, and very large datasets may go un-analyzed to the point of obsoletion.

To ease this bottleneck, OnRamp Bio offers services that empower researchers with insights that they can understand and put into action.

Software as a service: accessible bioinformatics for non-experts

OnRamp Bio has made significant progress in making bioinformatics accessible to larger numbers of researchers. Earlier this year, OnRamp Bio launched a new software-as-a-service for RNA-Seq analysis, to meet the needs of researchers needing assistance in making decisions based on the large data sets yielded by RNA-Seq experiments.

Genomics big data and complex software analyses have historically required highly trained PhDs in Bioinformatics using complicated command-line tools. OnRamp Bio’s intuitive user interface, automated analyses and robust data management make it faster and easier for scientists, biologists, clinicians and other medical professionals to obtain interpretations of genomic data without the complexity of traditional deployments.

“IT complexity has stood in the way of progress for far too long. We’ve combined our deep knowledge of IT and biology to provide intuitive, integrated systems and services that accelerate mainstream adoption of NGS analyses within biotech and pharma,” said Tim Wesselman, CEO of OnRamp Bio. “For institutions focused on drug discovery, cancer research, diagnostic, or therapeutic development, OnRamp Bio can help show how to implement next generation sequencing to securely build into future research, while getting immediate answers more cost-efficiently.”

In addition to offering end-to-end genomic analysis services, OnRamp Bio recently made the news when it launched Rosalind™, the first-ever software platform specifically designed to simplify genomic analysis (named for one of the researchers who discovered the double helix structure of DNA).

Faces of OnRamp Bioinformatics

Jeremy Davis-Turak OnRamp BioJeremy Davis-Turak, VP of Bioinformatics, earned his Ph.D. in Bioinformatics and Systems Biology in the lab of Dr. Alexander Hoffmann at UCSD, researching kinetic models of co-transcriptional splicing.  In his studies, Dr. Davis-Turak developed analyses for RNA-seq, nascent RNA-seq, GRO-seq and MNase-seq that were intimately linked with mechanistic models.  He set up the Bioinformatics Core at the San Diego Center for Systems Biology, optimizing pipeline for RNA-seq and ChIP-seq.  

 

Jean Lozach OnRamp BioJean Lozach, Chief Technology Officer, joined OnRamp Bio after more than 25 years experience in Genomics, Bioinformatics and Information Technology at Illumina and UCSD. Jean brought deep experience and knowledge of biology, wet lab operations, microarrays, and next generation sequencing together with advanced bioinformatics, software development and enterprise IT infrastructure. Jean is recognized as an industry expert in genomics and bioinformatics, and has led tens of successful customer deployments of next generation sequencing and informatics systems.

Roshni Patel OnRamp BioRoshni Patel, Bioinformatician, has helped complete many projects for OnRamp Bio’s clients. She earned her BS of Bioinformatics from the University of California at San Diego, and she is passionate about breaking down workflow complexity, improving data metrics and visualization.

 

 

What Science Exchange Requesters are saying about OnRamp Bioinformatics

OnRamp Bio’s storefront shows several testimonials from Science Exchange requesters. One review, in particular, applauds both the breadth and quality of their services: “I highly recommend OnRamp for their Bioinformatics expertise. I have worked with them on several genomics and metagenomics projects and the team is professional, completes the work on deadline and budget, and generated results we hadn’t expected. OnRamp will work with you every step of the way, from project inception, through interfacing with sequencing partners, through developing novel informatics solutions for your project. OnRamp’s bioinformatics platform has many unique attributes that make it appealing, but their data and analysis tracking is just amazing: provenance for all your analyses from the minute the sequences arrive.”

 

Visit the OnRamp Bio storefront today to request some quotes!

 

New on Science Exchange: ActiveMotif, Optopatch, & CV Tox for World Heart Day

September 20, 2017 | Posted by Team in Drug Discovery, New Innovations, Research |

by Chandreyee Das, Ph.D., Senior Content Manager, Science Exchange | www.scienceexchange.com

We observe World Heart Day at Science Exchange by highlighting a novel technology for assessing cardiac safety, from the Efimov Lab at George Washington University. Other newcomers on our platform that we present to you are ActiveMotif, Oncodesign, QurAlis, and Worldwide Clinical Trials.

ActiveMotif: Time to RIME (Rapid IP-MS of endogenous proteins)

It’s the 20th anniversary of the discovery of chromatin — and researchers can treat their favorite chromatin samples to ActiveMotif’s RIME service (Rapid immunoprecipitation mass spectrometry of endogenous

RIME Method ActiveMotif

RIME service from ActiveMotif includes nuclear isolation, sonication, IP, purification, tryptic digestion, MS, and data analysis

proteins). It is an ideal method for identifying transcriptional cofactors and other associated proteins within multi-protein complexes, and is often performed in parallel with ChIP-seq.

A leading provider of kits and services for studying gene regulation (both genetic and epigenetic), ActiveMotif is no stranger to chromatin. RIME is just one of a comprehensive menu of gene regulation services that ActiveMotif offers through Science Exchange — visit the storefront to browse their capabilities.

 

QurAlis: Harvard team uses Dead Sea microbes in novel assays

Founded in May 2017 by Clifford Woolf, Professor of Neurology and Neurobiology at Harvard Medical School, Kevin Eggan, Professor of Regenerative Biology at Harvard, Kasper Roet, Harvard Research Fellow, and Q-State Biosciences, QurAlis focuses the power of Q-State’s powerful, 100% optical electrophysiology platform on novel, stem cell-derived, disease-in-dish models of ALS.

It’s a Dead Sea microorganism that is the basis of the enabling Q-State technology. QuasAr proteins, derived from this microbe, respond to action potentials and synaptic signals by emitting near-infrared fluorescence. These Optopatch assays thus deliver higher throughput and information content than traditional patch clamp assays, and they also provide better resolution and lower phototoxicity than other optical screening tools.

We’re very excited to have QurAlis join Q-State Biosciences on our network, giving neurobiology researchers easy access to the expertise of the QurAlis team.

 

Worldwide Clinical Trials: Early phase services now available on Science Exchange

In the high-stakes service category of clinical trials, Worldwide stands out. In fact, Worldwide’s Chief Medical and Scientific Officer, Michael F. Murphy, M.D., Ph.D., was recently named one of the PharmaVOICE 100 Most Inspiring People of 2017 — for the impact of Dr. Murphy’s dedication to innovation.

Continuously working to improve trial design and patient outcomes, Worldwide now offers early phase services on the Science Exchange network. Click on the Worldwide storefront to access this major global CRO without needing a separate contract.

 

Efimov Lab: Predictive preclinical models of cardiovascular toxicology

An apt addition to the Science Exchange platform, in time for World Heart Day (September 29!), is the Efimov Laboratory at George Washington University.

Known around the world as a leader in cardiovascular science and biomedical engineering, Dr. Igor Efimov and his team developed a method for optically mapping organotypic cultures of donor human heart slices, enabling users to test the cardiac safety and efficacy of therapeutic candidates.

The culture method preserves heart tissue architecture and extracellular matrix — aspects of heart health that cannot be revealed by iPSC-derived cardiac cells or other traditional assays for cardiovascular toxicology. Visit the lab’s storefront for a list of their recent exciting publications — this is clearly a team to watch.

 

Oncodesign: Preclinical assessment of anti-cancer therapies

True thought leaders in the field of preclinical drug discovery and development, Oncodesign made the news last year when it partnered with Bristol-Myers Squibb to develop novel macrocyclic candidates and test them using their proprietary xenograft models and imaging technology.

Now, Oncodesign’s services are easily accessible to Science Exchange requesters. We get extremely excited thinking that a requester on our platform with a promising therapeutic candidate may now use Oncodesign’s Predict®, Chi-mice®, Pharmimage® and other platforms to characterize their candidate, speeding it along the path to potential cancer patients. Start a conversation with this leading CRO by submitting your Scope of Work here.

 

 

Connect with a new provider today!

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The Robotic Cloud Laboratory for the Life Sciences: Transcriptic

September 20, 2017 | Posted by Team in Drug Discovery, Lab Profiles, New Innovations, Research |

Transcriptic LogoBy Natalie Foote, Director of Service Provider Operations, Science Exchange | www.scienceexchange.com

 

In this Provider Innovation Profile, we’re proud to feature Transcriptic, whose automated cellular and molecular biology platform enables scalable life science research with flexibility and precision.

Automation is a rapidly advancing area of biotechnology, and Science Exchange hopes to give our researchers access to unique robotics platforms while helping them save on equipment costs and manage laboratory space limitations.

Transcriptic’s robotic cloud lab paradigm means biologists can be running experiments on the other side of the planet from their lab, leveraging a bank of robotic workcells for massive experimentation.

Transcriptic frees researchers to focus on the creative aspects of their science by providing faster, more reliable and repeatable processes with vastly lower capital costs than previously possible.

Differentiators: Transparency, flexibility, multiplex-ity

Transcriptic Robotic Workcell

Multiple integrated automated devices per workcell

  • Transparency: No other service provider on the planet can tell you exactly how they run an experiment on the user’s behalf. Transcriptic provides deep transparency into how users’ experiments were run by executing experiments exactly as specified and also providing retrospective diagnostic data on individual instrument performance during the experiment.
  • Flexible robotics: Being a robotic cloud lab, the Transcriptic system can dynamically provision robotic resources to process samples for users. For example, the system might start the week at a scale of one plate and end the week on hundreds of plates. Users only pay for the resources they use, reaping the reproducibility and throughput benefits of robotics without any of the overhead.
  • Easy multiplexing: The Transcriptic web application makes it easy as checking a box to detect an additional analyte in your sample. When it’s that easy, you can perform multiplexed quantiation of more analytes, starting to generate a more accurate picture of the phenotypic state of your sample.

Featured Service: Mesocale Discovery (MSD) Assay

The MSD assay, validated in many bioanalytical methods per U.S. FDA and EMA guidances, is offered as a service by Transcriptic. The Mesoscale Discovery Sector S 600 instrument is fully integrated with the Transcriptic robotic cloud lab.

The MSD S 600 instrument performs multiplexed detection of up to 10 analytes per well, ensuring the highest data-to-sample quantity efficiency, in immunoassays. Multiple assay panels are available from the V-Plex line, all conducted with complete automated precision by robots in the cloud. Custom panel assays are also available through the MSD U-Plex system.

Why requesters choose Transcriptic

Transcriptic, in collaboration with multiple biopharma companies and non-academic laboratories, has delivered many peer-reviewed publications and conference presentations.

Transcriptic presented one interesting study at SynBioBeta 2016. In collaboration with EpiBiome, Transcriptic’s automated platform provided a robust, reproducible and high-throughput method for on-demand microbiome characterization. This workflow captured sample prep through NGS and sequencing analysis in 7-10 days, allowing for fast, iterative cycles of microbiome screening.

Visit the Transcriptic storefront today to request some quotes!

 

New on Science Exchange: Nobel-worthy Nanosensors, MacroDSF, Fluidigm, and More

August 22, 2017 | Posted by Team in Drug Discovery, Lab Profiles, New Innovations, Research |

Nobel-worthy nanosensors

In 2007, Charles Lieber, the Harvard scientist who many say is in the running for a Nobel prize, co-founded Vista NanoBioSciences to enable drug discovery researchers to use his team’s nanosensor technologies for label-free, ultrasensitive detection of proteins, nucleic acids, and even single viral particles.

Functionalized Nanowires Vista NanoBioSciences

Vista NanoBioSciences’ ultrasensitive biomarker detection platform (left) uses functionalized nanowires (“NW”) that respond to interactions with individual biomolecules.

Vista NanoBioSensor

Now available through Science Exchange, Vista NanoBioSciences offers biomarker assays using its portable NanoBioSensor™ and BioTracker™ platforms. Vista’s NanoBioSensor precisely detects and measures biomarkers in a finger-stick drop of blood, other bodily fluid, or tissue culture – without labeling and in less than 10 minutes. Vista’s BioTracker provides continuous monitoring of dynamic changes in the targeted analytes of any biological material.  Both devices are portable, exhibiting very high sensitivity (10³ increase over ELISA), high specificity, across multiple logs of concentration, in real time.

Taking the pain out of protein purification with MacroDSF

Empowered by high-throughput protein purification and structure determination technologies, structure-based drug discovery is enjoying a resurgence.

NovAliX, a new provider on the Science Exchange network, gives you access to the ProteoPlex MacroDSF platform, an exciting tool for rapidly optimizing conditions for protein purification and crystallization.

The instrument quickly optimizes  protein concentration, pH value, salt, buffer, stabilizing additive, etc — potentially increasing a purified protein’s stability or even the resolution of its crystal structure!

NovAliX also offers a broad range of biophysical characterization services to provide a complete picture of the protein of interest.

Fluidigm custom assay development

Interested in Fluidigm’s powerful mass cytometry and microfluidics platforms, but lack the resources to design the perfect assay?

Now you can take advantage of Fluidigm’s expertise using the company’s own team of assay development scientists. Through Science Exchange, you can order custom assays for Fluidigm’s CyTOF®, Helios®, and integrated fluidic circuit-based platforms.

Oncology, from ABL1 to ZAP70

Based in Freiburg, Germany, ProQinase has been supporting oncology research for 16 years. Now on Science Exchange, ProQinase offers biochemical assay services (such as kinase screens), cellular assay services (such as proliferation, invasion and spheroid assays), and in vivo assay services (including immuno-oncology and metastasis models).

The scientific staff at ProQinase are thought leaders in oncology research. At the 2017 AACR Annual Meeting, they presented a novel assay platform to distinguish ATP-competitive from non-ATP-competitive kinase inhibitors.

Medicinal chemistry and process optimization

If you’re looking for a full-service laboratory to execute your chemistry projects, you’ll be happy to see the addition of Kalexsyn, a chemical synthesis powerhouse based in Michigan, U.S.A, to the Science Exchange network.

Whether it’s developing novel scaffolds, SAR, modification of complex natural products or challenging macrocyclic peptides, Kalexsyn’s deep bench of Ph.D. chemists provides IP-enabling expertise.

The Kalexsyn team has produced over 1000 publications and patents and has served over 85 pharmaceutical and biotechnology companies.

 

Connect with a new provider today!

Are you new to Science Exchange? See how it works.

In vivo Phenotypic Screening: Melior Discovery

August 19, 2017 | Posted by Team in Drug Discovery, Helpful products, Lab Profiles, New Innovations, Research |

By Natalie Foote, Director of Service Provider Operations, Science Exchange | www.scienceexchange.com

Melior Logo

Phenotypic Screening Pioneer Launches Novel Analgesia Panel

In this Provider Innovation Profile, we’re proud to feature Melior Discovery, a pioneer of in vivo phenotypic screening and a leader in the area of drug repositioning.

Melior’s platform evaluates compounds through up to 40 different animal models representing 14 broad therapeutic areas, potentially uncovering therapeutic efficacy that might be undetected using traditional assessments.

Recently, Melior made the news with its novel opioidTRACE® Analgesic Profiling Platform. Given the need to develop low-abuse analgesics to address the opioid crisis, Melior has configured an in vivo platform aimed at specifically profiling opioid therapeutics and related analgesics.

The opioidTRACE® platform addresses the multiple features characteristic of opioids, including rodent models that evaluate acute analgesia, chronic analgesia, respiratory depression, GI mobility, and abuse liability. In addition to opioid testing, Melior has a wide array of animal models of analgesia ranging models of acute pain to chronic neuropathy models. 

[click to view larger view of opioidTRACE® animal models]Opioid Trace In Vivo Models

Backed by Expertise in In Vivo Screening

Melior’s new panel is just the latest demonstration of the team’s unique know-how in applying “production-mode” methods for in vivo screening across multiple therapeutic areas. Its proprietary theraTRACE® platform enables rapid and cost-effective identification of new therapeutic potential by systematically screening candidates in a diverse array of validated in vivo disease models.

Fibrosis is another disease area for which Melior’s panels have exemplified the utility of in vivo  phenotypic screening. Melior has validated models of liver and lung fibrosis; download the validation data for these models from the Resources section of Melior’s Science Exchange storefront.

Why Requesters are Choosing Melior for In vivo Studies

Melior’s capability directly translates to efficiencies combined with high levels of quality for their clients. Positive ratings and testimonials illustrate the benefits that attract repeat business for Melior:

  • High reproducibility and predictive power of in vivo methodologies, models, and assays assuring high quality of data
  • Lower overall costs resulting from the availability of highly cost effective preclinical services from Melior
  • Rapid responses to requests for service and quick turnaround times for preclinical studies
  • Ability to rapidly customize, design, and modify models in response to requests for specialized in vivo services or changes in protocols or unexpected results at any stage of the study

Dr. Sridharan Rajamani, Senior Research Scientist at Gilead Sciences, said that his team chose Melior Discovery because they were responsive and cost effective.  “We are staying with them as a chosen scientific partner because of their thoughtful scientific input to experimental design and attention to detail,” said Dr. Rajamani. “Their expertise and flexibility allowed us to quickly adapt the study design and evaluate additional outcome measures to pursue unexpected activity.”  

Interested in working with Melior Discovery? Request a quote to start the discussion.

New Service Providers Available on Science Exchange

August 2, 2017 | Posted by Team in Drug Discovery, Lab Profiles, New Innovations, Research |
Image of Colon Tumor Cells courtesy of OcellO

Image of Colon Tumor Stem Cells courtesy of OcellO

If you aren’t exploring the latest cell culture models of human tissue for nonclinical and preclinical testing, you should be.

That’s the bottom line of today’s Science Exchange service provider roundup — three of the five newest service providers on our platform are experts in developing predictive models.

Advances in predictive model systems

Axiogenesis, based in Germany, develops iPSC-derived models of cardiac tissue, neurons, and other cell types. In late 2016, the company made the news when researchers at the United States FDA published a peer-reviewed study showing that Axiogenesis’s Cor.4U cardiomyocyte model was the most predictive model in cardiac safety tests. Last month, researchers at Wake Forest University used the Cor.4U model to develop a digitally trackable beating-heart biosensor. The future of cardiac safety clearly lies beyond hERG channel electrophysiology!

Generating tissue models with precise spatial resolution is possible using 3D bioprinting, in which Cypre Biotech is an expert. Based in San Francisco, USA, the company focuses on customizing the extracellular matrix of tumor microenvironment models to match certain cancer subtypes. Given the impact of new cancer drugs, including certain immunotherapies, on the tumor microenvironment, technologies such as that developed by Cypre are going to be needed for testing safety and efficacy.

The third service provider in this roundup excelling in the development of clinically relevant microtissue models is OcellO, headquartered in the Netherlands. Researchers at OcellO have published numerous peer-reviewed studies showing how combining three-dimensional tissue culture with high-throughput imaging can enable efficient, automated screening and phenotypic profiling. Their most recent publication showed that phenotypic screening of kinase inhibitors could reveal potential new targets for polycystic kidney disease (view abstract in the Resources section of the OcellO storefront).

Analytical methods for translational research

As model systems advance in complexity and throughput, analytical methods must keep pace. Two service providers new on Science Exchange are known for their expertise in developing reliable analytical methods.

Pangaea Oncology is one of the most prestigious laboratories in the world in the fields of molecular diagnostics, pathology, and related analysis services for translational research. We are thrilled to have the Pangaea team, led by expert Dr. Rafael Rosell and Nobel laureate Dr. Santiago Ramón y Cajal, join the Science Exchange platform! Pangaea Oncology was the first laboratory in Spain to be accredited to perform certain genetic tests for cancer in serum/plasma samples, advancing precision medicine.

We also bring you Metis Laboratories, whose analytical expertise centers on radiotracer-based assays. These assays remain one of the most sensitive and specific platforms for assessing ligand binding and compound distribution; however, complex handling requirements mean that outsourcing these studies is far more practical than developing radiotracer assays in house.

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