New on Science Exchange: VR Tech, Cancer Genetics, Stem Cell-based Organoids

October 26, 2017 | Posted by Team in Innovation Highlight, New Innovations |

Chandreyee Das, Ph.D. | Senior Content Manager, Science Exchange | www.scienceexchange.com

Nanome Virtual Reality

Virtual Reality Software: Explore biology at nanoscale

From “Fantastic Voyage” (1966) to “A Wind in the Door” (1973), fiction has adored the idea of exploring the body at cellular and molecular levels. Now, virtual reality (VR) software, combined with the computational power afforded by blockchain technology, makes such journeys possible.

For your next computer-aided drug discovery/development (CADD) project, especially if you are collaborating with researchers across multiple sites, try molecular visualization using VR technology — now available from Nanome through Science Exchange.

Visit the Nanome storefront to connect with their team!

 

Cancer Genetics: Connect patients to discoveries

It’s a great day for precision medicine, with the unveiling of the first global directory of patient-derived xenografts (PDX).

Despite the attention given to precision medicine, however, less than 5% of cancer patients are participating in clinical trials. In the discovery phases of R&D, obtaining biospecimens of specific genotypes is also a continuing challenge.

Oncologists on Science Exchange can now accelerate their research with Cancer Genetics, Inc., a global CRO with a history of thought leadership in precision medicine.

Start a project today with Cancer Genetics, Inc.

 

Stem Cell-based 3D Organoids: Predict Preclinical Efficacy and Toxicity

3Dnamics Organoid Hippocampus

Organoids, particularly brain organoids, have enabled breakthrough research in Alzheimer’s disease, glioblastoma, and even ZIKA virus-induced microcephaly. By using pluripotent stem cells as a source of the multiple cell types present in an organoid, preclinical researchers can recapitulate in vivo-like tissue architecture and cellular heterogeneity.

Many of these discoveries were made by the founders of 3Dnamics, a new service provider on the Science Exchange network. The 3Dnamics team was built by stem cell pioneers and neuroscientists at Johns Hopkins University School of Medicine. If you are in the process of developing a model system for your preclinical or discovery-phase research, take advantage of 3Dnamics’ expertise.

Visit the 3Dnamics storefront

 

Small Biotech Stories: American CryoStem

October 29, 2013 | Posted by Brianne Villano in New Innovations |

American_CryoStem_Logo_larg

Some companies skirt regulations, opting instead to go off the radar. American CryoStem‘s Anthony Dudzinski‘s first words to me on the phone during our discussion were, “We follow the rules.” They’ve accumulated the greatest depth of adipose tissue-based cellular technology research relative to creating their laboratory and processes at a clinical cGMP level, and they’ve done it by actively engaging FDA consultants in the process.

Anthony F. Dudzinski, COO at American CryStem

Anthony F. Dudzinski, COO at American CryoStem

They’re looking at adipose-derived stem cells – also known as mesenchymal cells. ‘Mesenchymal’ was the original name of cells that came from bone marrow, and the two types are 98-99% identical, but there are some difference with the protein markers and capabilities of adipose vs. marrow cells.

Marrow cells are better for blood-borne diseases like lymphomas, whereas adipose-derived stem cells seems to be much more effective than marrow for structural issues. The concentration of adipose cells per gram of source material is actually 500-1000x greater than bone marrow from same patient. They have the ability to differentiate into a multitude of other cells including chondrocytes. This has incredible potential for how doctors treat sports injuries and aging issues.

Anthony set the stage for the importance of the research,”Most sports or age injuries are due to ligament or cartilage damage to the extent that most of them are bone on bone. So what if we could take Mrs. Smith who’s 55 and played tennis most of her life but can’t play anymore and doesn’t want to have knee replacement surgery. We can take cells out of the fat in her own body, attach them to a scaffold to induce chondrocytes, insert them into the meniscal cartilage area, and as time goes by with normal rehabilitation, her body regrows cartilage in her knees and her pain is gone.”

Anthony is excited about the implications for creating tissue for repairs, wound healing, burns, tendon injury, etc., all coming out of cells taken from adipose tissue. Read the rest of this entry »

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