Dan Knox, Co-Founder And COO Will Be Speaking At LabLaunch in Monrovia, CA

April 5, 2016 | Posted by Team in Company, Events |

Dan Knox, Co-Founder and COO, will be speaking at LabLaunch in Monrovia, CA, about how to use Science Exchange to order experiments from the world’s best labs. This event is part of the “Biotalk” seminar series which is a monthly educational networking event to support the current and potential biotech entrepreneurs of Los Angeles.
Agendadan
6:00pm-Networking and Refreshments
6:30pm-Presentation
When
Thursday, April 14, 2016 from 6:00 PM to 7:30 PM (PDT)

Where
LabLaunch-Monrovia – 605 Huntington Drive #103, Monrovia, CA 91016

Register

Science Exchange Announces $25 Million in New Funding Led by Maverick Capital Ventures

March 23, 2016 | Posted by Team in Company, Science Exchange News, Uncategorized |

Science Exchange, the leading marketplace for scientific research, announced today that it has raised $25 million in new funding. The latest funding round was led by Maverick Capital Ventures and also included participation from Union Square Ventures, Index Ventures, YC Continuity Fund, Sam Altman, and others.

Since its founding in 2011, Science Exchange has become the world’s leading marketplace for scientific research services. The company provides secure access to a network of 1000s of screened and verified contract research organizations (CROs), academic labs, and government facilities that are available to conduct experiments on the behalf of scientists. The Science Exchange platform has been used by scientists from over 2,500 different companies and organizations. The company has experienced significant growth in the last 12 months, including seeing the total transactional volume of experiments conducted through the Science Exchange platform grow over 500% in 2015.

“Over $40B a year is spent on outsourced scientific research by the top 50 pharmaceutical companies alone. Much of this spend is highly fragmented across thousands of individual scientific service suppliers, and this fragmentation represents a challenge to both individual scientists and sourcing procurement departments,” said Dr. Elizabeth Iorns, Founder & CEO of Science Exchange. “The Science Exchange platform solves this challenge: we provide scientists with efficient access to a diverse network of qualified suppliers under a single relationship, and at the same time we provide sourcing departments with more information and control over their outsourcing spend.”

8 of the top 10 pharmaceutical companies now use Science Exchange, viewing it as a way to efficiently access innovative external resources. Science Exchange also helps tackle one of the most significant challenges facing the highly-trained researchers at these companies: time and resources spent identifying and managing outsourcing contracts. James Lillie, VP In Vitro Biology at Genzyme (a Sanofi company), was recently quoted as saying, “We now look at the Science Exchange as the best way of finding new outsourcing opportunities with collaborators and CROs. We’re shifting more of our efforts for new outsourcing contracts there.”

As part of the Series B, Maverick Capital Ventures Managing Partner David Singer (former Founder/CEO of Affymetrix, GeneSoft Pharmaceuticals, and Corcept Therapeutics) will join the company’s board. “We spent a lot of time evaluating the growing market for outsourced scientific services. We concluded first, that there is an expanding market need for a marketplace to aggregate the thousands of suppliers, and second, that Science Exchange is poised to become the ubiquitous platform for scientific outsourcing,” said Singer.

Andy Weissman, Partner at Union Square Ventures, who has been on the company’s board since 2013, agrees. “With over 500% growth in marketplace transaction volume in 2015 and some companies already spending over $1M each month on the platform, Science Exchange is the clear market leader,” said Weissman.

Science Exchange is headquartered in Palo Alto, CA, and has clients, including many large pharmaceutical companies, around the globe. The company has now raised over $30 million and plans to use the new funding to expand its team in all areas including product, engineering, sales, marketing, and customer success. The full list of investors in the latest round is Maverick Capital Ventures, Union Square Ventures, Index Ventures, OATV, YC Continuity Fund, Windham Venture Partners, Collaborative Fund, Fenwick & West, Jose Suarez (CEO of TEDMED), Sam Altman, Steve Case, Kal Vepuri, Jenny Haeg, Alexander Levy, Paul Buchheit, and Silicon Valley Bank.

 

 

 

A Voyage Through the PacBio Genome Galaxy

March 16, 2016 | Posted by Team in Science Exchange News |

We are pleased to support the Genome Galaxy Initiative from PacBio. SMRT Sequencing Technology manufacturer PacBio recently unveiled the Genome Galaxy Initiative. The Genome Galaxy Initiative, based on the Experiment platform, supports expedited, open-access genomic projects. It’s a central location for SMRT Sequencing-based projects seeking crowdfunding, and fosters a community of scientists and patrons interested in asking research questions that can only be answered with long-read sequencing. As high-quality genome assemblies from the PacBio RS II and the Sequel System have become even more affordable and accessible, partnering with Experiment is a great fit. Through this program, even more scientists will have access to the most comprehensive view of genomes, transcriptomes, and epigenomes from SMRT Sequencing.

The Genome Galaxy Initiative

One of the initiatives flagship participants is the Kakapo 125 Project. An effort to sequence the genomes of every individual in the entire kākāpō species. This project was made possible thanks to the high quality reference genome generated by Dr. Jason Howard at Duke’s Jarvis Lab using SMRT Sequencing technology.

Kakapo Jasira

Other projects in the Genome Galaxy include efforts to find bacteria within ticks to stop diseases, as well as an investigation into the incredible nitrogen capturing properties of the fern Azolla. In addition to fostering a growing community of SMRT Sequencing related projects PacBio is also offering a grant program exploring the “most interesting genome” as voted for by the public. 2016 applications for this grant are now closed with a winner to be announced in April.

Science Exchange is also assisting in the Genome Galaxy Initiative with a number of its projects including the Kakapo 125 being managed on its platform. As well as hosting many of the projects Science Exchange is also the easiest and most comprehensive place to find SMRT Sequencing service providers.

science-exchange-smrt-sequencing

The Genome Galaxy Initiative is another great example of the industry coming together to support open access science and to help out with funding at the grassroots level. Science Exchange is excited to be affiliated with this initiative and looks forward to seeing many new and exciting stars being discovered there.

Visit Science Exchange and See Our New Look!

February 25, 2016 | Posted by Team in Company, Helpful products, New Feature, Science Exchange News |

For many people who use Science Exchange, a visit to the homepage is the first step in accomplishing their research objective. For requesters, service providers, or anyone using our network, the web experience is a crucial part of each project. With that in mind, we are excited to announce that we have refreshed the site, including an entirely new homepage. We have kept the same handy tools you will need to start and manage your research project, but improved the look and feel of some key pages. Search our marketplace for thousands of Science Exchange Verified Providers and request a quote in minutes. If your project is more specialized, you can partner with one of our staff scientists to find a perfect fit for your research needs with our concierge service. Every project is covered by the Science Exchange Guarantee, ensuring that your research can begin quickly, safely, and with complete IP protection. Science Exchange is an ideal partner for researchers who want to focus on science instead of sourcing, and progress instead of payment terms. We work with the world’s best suppliers to make scientific discovery faster, easier, and more reproducible. Providing scientists with a single relationship which manages compliance, contracts, and payments allows them to focus on the research goal at hand while collaborating with our cutting-edge providers. We think breakthrough discoveries should happen at the rate of science, not protracted negotiation. Take a look at our ever-growing network to explore how we can help with your next project.Screen Shot 2016-02-25 at 4.34.47 PM

Kakapo 125 – Sequencing the genomes of all known kākāpō

February 1, 2016 | Posted by Team in Science Exchange News |

Kakapo-2

Science Exchange is pleased to announce it will be collaborating in the Kakapo 125 Project. The objective of this project is to sequence the genomes of all 125 known living kākāpō.

The kākāpō is a species of large, flightless, nocturnal, ground-dwelling parrot of the super-family Strigopoidea endemic to New Zealand. It is critically endangered; as of February 2016, the total known population is only 125 living individuals.

The Kākāpō Recovery Team relies on genetic information to manage kākāpō matings in order to ensure maximum genetic diversity. Having the whole genome of all remaining individuals would allow the team to better understand the relatedness of individuals to optimize breeding.

New Zealand Genomics LtdSequencing of the first 40 kākāpō genomes is already underway at Science Exchange’s newest New Zealand based service provider New Zealand Genomics Ltd (NZGL).

The Kakapo 125 Project is the latest project organized by The Genetic Rescue Foundation. The Genetic Rescue Foundation is a not-for-profit organization dedicated to advancing scientific techniques that enable us to preserve global biodiversity. It was founded by Science Exchange software engineer and citizen/wannabe scientist David Iorns.

The Genetic Rescue Foundation has successfully raised funding for the first 40 genomes but is actively fundraising to complete the remaining 85. A core component of this fundraising will be the Experiment.com crowdfunding campaign that will run from February 1st – April 30th 2016. If you would like to help save one of the world’s most unique and charismatic birds as well as playing a part in sequencing the genomes of every individual in an entire species please contribute to the project.

Fund this project

The Kakapo 125 Project is a collaboration between a number of government, nonprofit, iwi and commercial entities.

Kakapo 125 collaborators

All of the collaborators have played an important role in the project to-date. The following individuals have been particularly critical to the projects progression.

  • Andrew Digby, Science Advisor Kakapo/Takahe DOC – Andrew works for the Department of Conservation (DOC) in New Zealand. He is leading the Kakapo 125 Project and conceived the idea of sequencing the genomes of the entire kākāpō species.
  • Bruce Robertson, Molecular Ecologist, Otago University – Bruce’s research focuses on conservation genetics and molecular ecology. He has been working on kākāpō genetics since 1996.
  • Jason Howard, Neuroscientist, Duke University – Jason (in Erich Jarvis’s lab) and his team at Duke were the first to sequence the kākāpō genome.

Sequencing the genomes of all 125 known living kākāpō is an ambitious and exciting endeavor that will help save one of the world’s most endangered species. It will also create a rich, open access genetic dataset that will be the foundation of some compelling research in years to come. Science Exchange is proud to add the Kakapo 125 Project to its long list of impactful scientific projects facilitated and managed via its platform.

Download information about the project in a distributable, media friendly format.
Download press kit


Learn more about how Science Exchange can accelerate your research.

Koliber Biosciences Is Using Science Exchange To Develop Their Probiotic

January 20, 2016 | Posted by Team in Conferences, Events, Small Biotech Stories |

At the Blue Sky Bio Competition held during the SynBioBeta SF 2015 meeting, three finalists presented their ideas to the conference audience. They each hoped to win the prize resources in order to get the boost they needed to bring their ideas to fruition. Science Exchange sponsored this event, and presented the winners with $100,000 in credits to be used on the Science ExchEwa-Lisange platform. In the end, the audience decided to divide the winnings among the three finalists. Ewa Lis, founder and CEO of Koliber Biosciences and one of the winners, presented her ideas about probiotics and depression.

Ewa hopes to tackle the problem of depression. They propose to develop a probiotic strain that will produce a serotonin precursor of tryptophan directly in the gut. A probiotic supplement, especially if available over the counter, is more likely to be accepted by the large population of people that currently avoid medical treatment. It solves the problem of tryptophan degradation in the stomach and doesn’t require long treatment.

The market need for new depression treatments is clear. Depression affects 350 million people worldwide and results in $30 billion of economic loss. Two thirds of people suffering from depression do not seek medical treatment despite the existence of treatments. Moreover many failed treatments are due to patients stopping the medication themselves, often due to side effects.

Ewa and her team will use Science Exchange to develop probiotics that will ameliorate the effects of depression. To develop the strains they will use information from whole genome sequencing, RNA sequencing and analytical chemistry, services readily available via Science Exchange. Combined with their expertise in strain engineering and machine learning, they will be able to leverage the Science Exchange services to accelerate their research.

Science Exchange has many labs that can help Ewa and her team. For DNA sequencing, labs like Macrogen, Laragen, Quick Biology, Affiliated Genetics, ACGT and Applied Biological Materials can perform the work. For RNA sequencing, there are over 60 labs that can help Koliber Biosciences. In addition to these services, Science Exchange has labs that specifically focus on gut microbial community studies such as Second Genome. Lastly, Science Exchange offers many, many labs that perform standard studies such as amino acid analysis and compound synthesis. Science Exchange is the right resource to help Koliber Biosciences get started.

 

Science Exchange Supplier Spotlight: University of Wisconsin Cardiovascular Physiology Core Facility

January 15, 2016 | Posted by Team in Core facilities |

The Cardiovascular Physiology Core Facility, with over 35 years of research experience, provides researchers with a resource for creating and studying animal models of disease.

While the central focus of the facility is cardiovascular research, the techniques employed are often useful to investigators in other fields. Currently, the facility is conducting studies into diabetes, bone growth, drug toxicology, and gene therapy in liver and skeletal muscle, as well as cardiovascular disease. One of the most popular services provided by the facility is evaluation of the cardiovascular phenotype of transgenic mice.

The facilities include:

Complete animal catheterization laboratory and fluoroscopy suite
Complete animal catheterization laboratory and fluoroscopy suite


Microsurgery Stations
Microsurgery Stations

• Fully-equipped small and large animal operating theaters
• State-of the art echocardiography for large and small animal models
• ECG and blood pressure monitoring via telemetry
• Exercise training and testing
• Physiologic recording equipment
• Sonomicrometry

You can learn more about this lab’s offerings on their storefront.

Science Exchange Won Four Grants from the International Initiative for Impact Evaluation (3ie), which is funded by the Gates Foundation, to reanalyze published articles dealing with health in developing countries.

October 28, 2015 | Posted by Keith Osiewicz in Company, Reproducibility |

We won four grants to reanalyze four published journal articles in the field of public health. These grants covere four subjects: Cash transfers and sexually transmitted diseases, the necessary training of healthcare providers, circumcision and HIV and the affect of the US government’s spending in Africa on mortality. The grants come from 3ie, which is funded by the Gates Foundation. The work will be performed by a lab listed on Science Exchange: the University of Nebraska’s Center for Collaboration on Research Design and Analysis.

The grants cover various aspects of healthcare in developing countries. The first grant will analyze a paper published in Lancet in 2012 by Sarah Baird, Richard Garfein, Craig McIntosh and Berk Ozler. This paper, Effect of a Cash Transfer Programme for Schooling on Prevalence of HIV and Herpes Simplex Type 2 in Malawi: A Cluster Randomized Trial, showed that direct cash transfers decreased the prevalence of HIV and herpes simplex virus 2 (HSV-2) as well as the sexual behavior of the young women receiving transfers for 18 months. The second grant will reanalyze the 2012 paper published in Lancet, Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. This paper examined the affect of using nurses, instead of scarce doctors to administer anti-retroviral treatment to patients with HIV. They found that STRETCH was not inferior to standard care and supports expanding the pool of ART prescribers beyond doctors to nurses. The third grant seeks to replicate the paper from 2011, Effect of circumcision of HIV-negative men on transmission of human papillomavirus to HIV-negative. This paper addresses an important question about HPV prevention and it evaluates male circumcision as a HPV prevention strategy among rural African HIV-negative women who lack both resources and vaccines that cover the existing high-risk HPV genotypes. The results from Wawer et al. (2011) provide strong support for use of male circumcision for HPV prevention and cervical neoplasia in HIV negative female partners. The fourth grant will examine a study published in JAMA in 2012 titled, HIV Development Assistance and Adult Mortality in Africa. This study investigates the relationship between increased funding to countries receiving aid through the President’s Emergency Plan for AIDS relief (PEPFAR) and adult mortality more generally. PEPFAR is the initiative developed by President George W Bush which increased funding to select countries from 2004 to 2010. The main finding of the paper is that PEPFAR countries had dramatically lower mortality than non-PEPFAR countries.

Dr. Nicole Perfito, Science Exchange lead for these projects says, “Using Science Exchange to gather the resources to reanalyze these experiments means it can be done faster and cheaper than would normally occur.

The analysis of these papers will bring extra scientific rigor to the study of health in developing countries. The University of Nebraska’s Center for Collaboration on Research Design and Analysis will do the analysis of these journal articles under the direction of Dr. Nicole Perfito at Science Exchange. Once the results are complete, these replicated studies will be published in peer-reviewed journals.

The UCLA Microarray Core just received new HiSeq 3000 and HiSeq 4000 instruments

September 28, 2015 | Posted by Keith Osiewicz in Uncategorized |

The UCLA Clinical Microarray Core/JCCC Genomics Shared Resource (CMC/GSR), directed by Dr. Xinmin Li, just received new Illumina HiSeq 3000 and HiSeq 4000 instruments. These instruments greatly expand the lab’s ability to sequence nucleic acids and perform many next generation sequencing applications including whole genome and whole exome sequencing. Here is a table from the Illumina website describing the capabilities of these new instruments.

illumina-3-4-use

View all of the the UCLA Microarray Core’s services.

 

How does Science Exchange rank service providers?

September 28, 2015 | Posted by Keith Osiewicz in How To |

At Science Exchange, we want to make it easier to find the best service providers to help you with your project. Our product development team has built features such as a search box that displays results as you type, and search results that are filterable to help you quickly find what you are seeking. These features are powered by a core search algorithm that references important service provider-specific information to rank the search results.

Blog-search-1

Once you enter a search, the algorithm determines the relevancy of search results based on the keyword you entered. The algorithm then looks at the service provider storefronts that pass through this filter and ranks them based on a service provider score. This score is calculated by looking at the following features:

 

Responsiveness

Because we want requesters to hear back as soon as possible, service providers that respond to requests for quotes in a timely fashion have higher scores. We value providers who have consistently responded to their requests quickly. Plus, it is the polite thing to do. You are never penalized for declining requests. Declining a request is considered responsive behavior.

Productivity

The service provider that regularly and consistently completes orders has a higher score and will rank higher in the search results. Requesters are more comfortable working with proven providers. If you are a provider, learn more about sending your own quotes to help boost your productivity quotient.

Positive Recommendations

At Science Exchange, we offer people the chance to review service providers, and those that have many good reviews are ranked higher in the search results. However, we also take into account how long a service provider has been on Science Exchange. If you request a service from a lab, please write a review after the project is finished. If you are a service provider, please solicit recommendations from the requesters with which you work. You can also ask previous collaborators for endorsement; learn more.

New Lab Boost

We value our long-time Science Exchange service providers, but we also want to introduce new providers to the community effectively. Therefore, new providers receive a rankings boost during the first month after they join Science Exchange. If you are a service provider, take advantage of this boost by responding quickly to any requests and ideally completing projects so that when the boost goes away at the end of the first month, you will still appear high in the search results.

We will continue to optimize the search experience on Science Exchange. Check this blog regularly to stay informed of any changes.

 

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