We’re excited to announce that our introductory article and the first three of our Registered Reports have been published by our partner eLife.
In “An open investigation of the reproducibility of cancer biology research”, the Reproducibility Project: Cancer Biology core team details the impetus for and the specific goals of the project:
“The resulting open methodology and dataset will provide evidence about the reproducibility of high-impact results, and an opportunity to identify predictors of reproducibility” (1).
The first three Registered Reports are:
- Registered Report: Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
- Registered Report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
- Registered Report: Melanoma genome sequencing reveals frequent PREX2 mutations
In addition, Sean Morrison, director of the Children’s Medical Institute at the University of Texas–Southwestern and a senior editor at eLife, has written an editorial introducing the Reproducibility Project: Cancer Biology, highlighting the role this project could play in beginning to reform scientific discovery methods to maximize reproducibility. He notes that:
“to be responsible stewards of the public’s investment in this work we have to maximize the pace of discovery and the efficiency with which discoveries get translated to the benefit of patients. By gauging the fraction of high-impact results that are not reproducible, we can consider what further steps should be taken to promote good science….[M]easuring the magnitude of the problem with efforts like the Reproducibility Project: Cancer Biology is an important step in the right direction” (2).
You can find all five articles on eLife’s website: http://elifesciences.org/collections/reproducibility-project-cancer-biology
With the publication of these Registered Reports, experimentation for the first three replication studies can begin. We are extremely proud to partner with the Center for Open Science and eLife to move the Reproducibility Project: Cancer Biology forward, and we look forward to the beginning of the data collection process!
Tracking our progress
You can keep track of the progress of the entire project here. We have made great strides in the last two months, moving many more projects along the pipeline. Our current status, as of December 2014, is detailed below:
Phase 1: A selection of key experiments are identified for each original paper
Phase 2: Protocols are drafted for each experiment
Phase 3: Protocols are transferred to Registered Report format
Phase 4: Protocols revised with help of original authors
Phase 5: Protocols revised with help of replicating labs
Phase 6: Registered Report is peer reviewed through eLife
Phase 7: Experimental work is begun by the replicating lab
Phase 8: Experimental work is finished
Phase 9: Analysis and evaluation of results
Phase 10: Replication Study is published in eLife for each original paper
1 Errington TM, Iorns E, Gunn W, Tan FE, Lomax J and Nosek B. Science forum: An open investigation of the reproducibility of cancer biology research. eLife 2014;3:e04333.
2 Morrison SJ. Reproducibility project: cancer biology: Time to do something about reproducibility. eLife 2014;3:e03981.