Whether you need high-throughput DILI screening, IND-enabling animal studies, or any other type of nonclinical safety assessment, you can accelerate your toxicology research by outsourcing with the Science Exchange Contracted™ network of verified providers.
Here are five recent additions to the network who can help advance your drug discovery and development programs — no additional MTAs, CDAs, NDAs, etc required.
The HµRELTox™ service combines three different measurements of cyto- and heptatoxicity of a candidate, measured across a 7-day, repeat dosing regimen.
How is this possible? HµREL’s primary hepatocyte co-culture models are particularly stable, long-lived, and metabolically competent.
Reliable toxicology starts with disease-relevant animal models, such as those from GD³, whose in vivo animal models span multiple therapeutic areas: oncology, metabolic diseases (NASH, diabetes, obesity), inflammation, and immunology. Based in New Jersey, the organization supports both GLP and non-GLP toxicology and safety studies with state-of-the-art animal housing and analytical core labs.
Attentive Science is the Kansas-based, new preclinical CRO led by the renowned safety pharmacology expert, Alfred Botchway, Ph.D., who founded and led Xenometrics until its acquisition. Attentive Science supports sponsors with many drug development services, including acute effect and dose range finding studies as well as subchronic and chronic toxicity studies. The team can mimic all intended clinical dose routes (PO, IV, IP, SC, IM, dermal, etc) in rodent and non-rodent models.
Pentagrit focuses on safety and efficacy studies in zebrafish models. Models include genetic and xenograft models that have been proven to replicate human disease progress and pathophysiology. Using zebrafish as a toxicology model has the potential to bring drugs up the pipeline faster.
Cytoscient, a northern California-based provider of cell-based toxicity assays, offers MTT, LDH and neutral red assays to measure cytotoxicity and cell viability. Choose from several cell types, including HepG2, 293T, NIH3T3, primary hepatocytes and others.
Cytoscient also offers screening of compounds in the 3T3 cell line to measure phototoxicity.