We’re ready for the Charles River’s 23rd Annual Biotech Symposium!

July 26, 2017 | Posted by Team in Conferences, Events, New Innovations, Workshops |

by Annie Chen, Event Marketing Specialist, Science Exchange | www.scienceexchange.com

We are excited to attend the 23rd Annual Biotech Symposium hosted by Charles River, a leading service provider on the Science Exchange network — and we hope to see you there! Join your colleagues and industry experts from Bluebird, Janssen, Pfizer, and Amgen in Carlsbad, CA September 11–13.

With five different session tracks, join Charles River to learn about:

  • Biotherapeutic development programs and related case studies
  • Biomolecules and modifications to prolong a molecule’s half-life
  • Preclinical development of inhaled therapeutics
  • Microphysiology systems for biotherapeutics

Arrive one day early and attend the pre-symposium workshop titled, Where Does My Protein Go and Why Does It Matter? The Role of PK/PD in Biotherapeutics on Sunday, September 10.

Discounted room rates are available until August 11 and special registration fees are available to SOT BTSS members.

Register Now!

Science Exchange Scientist Trains Minority STEM Students

July 7, 2017 | Posted by Team in Conferences, Science Exchange News |

We are proud of our own Dr. Gabriel Roybal-Jungemann, Senior Scientist and R&D Specialist at Science Exchange, who will be speaking this week at a career panel aimed at increasing STEM leaders of color. Promoting diversity in science is crucial to achieving Science Exchange’s mission of enabling breakthrough research.

Gabriel joined Science Exchange after 12+ years in biomedical research and teaching at minority-serving institutions. He is also an entrepreneur, having founded his first company in 2013 to help improve family health and address health disparities.

As a scientist of color, Gabriel will be speaking to minority STEM students about entrepreneurship and to encourage alternative careers and innovation.

Read more about the event below!

Gabriel Roybal-Jungemann


This week, a select cohort of underrepresented minority STEM students will begin their path to leadership. Science Exchange will be represented with the participation of Dr. Gabriel Roybal-Jungemann, Senior Scientist, Research and Development Specialist, as a Career Panel Speaker for the inaugural SACNAS Chapter Leadership Institute (CLI).

The CLI is led by Society for Advancement of Chicanos/Hispanics & Native Americans in Science (SACNAS) and funded by the Genentech Foundation. Dr. Roybal-Jungemann has been involved with SACNAS since 2005.

The institute, held July 7 – 8 at San Jose City College, is two full days of small group exercises, keynote speakers, leadership development workshops, networking opportunities, and extensive community building among selected participants from colleges and universities across California.

SACNAS Director of Programs, Mr. Rolando Madrid says the Genentech Foundation is the ideal partner to nurture a new generation of leaders. He notes, “We are proud to partner with the Genentech Foundation to launch our inaugural Chapter Leadership Institute. Genentech understands the importance of investing in our next generation of underrepresented minority scientists and is doing their part to ensure that the future is well developed and prepared to tackle the issues of the 21st century.”

Participants of the CLI are all part of the SACNAS chapter program, a national network of 115 student and professional chapters that work to strengthen community and peer support for minority scientists at the local and regional levels.

Ms. Tanya Beat, manager of the SACNAS Chapter Program, says, “The CLI will equip students with critical take-away tools including individual leadership plans, mentor-mentee relationships, and a rich network of peers and STEM leaders from California.”

Since 2009, SACNAS leadership initiatives have trained a cohort of 30 PhD-level scientists each year, making it the largest group of emerging STEM leaders of color in the country. With the introduction of CLI, SACNAS is expanding leadership training to the undergraduate and graduate student levels, nurturing leaders earlier in their educational and career trajectories.

View the entire SACNAS Chapter Leadership Institute Cohort.

 

About SACNAS & The Genentech Foundation

SACNAS is an inclusive organization dedicated to fostering the success of Chicanos/Hispanics and Native Americans, from college students to professionals, in attaining advanced degrees, careers, and positions of leadership in STEM. Considered the founder of the biotechnology industry, Genentech is leader in the discovery, development, manufacturing, and commercialization of medicines that treat patients with serious or life-threatening medical conditions. The Genentech Foundation focuses on three charitable giving goals: advancing scientific knowledge, enhancing health outcomes, and building strong communities to build real and lasting change.

 

Service Providers Aim for Cancer Moonshot at AACR 2017

April 7, 2017 | Posted by Diana Truong in Conferences, Drug Discovery, Events, Helpful products, New Innovations, Research |

Greetings from the AACR Annual Meeting!

This year, we heard Joe Biden’s report on the progress of the Beau Biden Cancer Moonshot Initiative, compared immuno-oncology combination therapies, and mulled over the use of CRISPR screening to finding epigenetically controlled loci.

Joe Biden delivers the Cancer Moonshot Initiative update at AACR 2017

We also checked out the groundbreaking research being done by service providers on the Science Exchange network. Their work directly addresses the recommendations made last fall by the Moonshot’s Blue Ribbon Panel, and we are excited to give cancer researchers rapid access to these technologies through the Science Exchange platform!

Here are a few highlights from our exploration of #AACR17:

First humanized mouse model of tumor growth in bone: Pharmatest and Taconic Biosciences

The Moonshot Initiative’s recommendations specifically called out the potential of humanized mouse models to recapitulate the cellular architecture and heterogeneity found in human tumors. Traditional preclinical models that lack functional interactions between tumor, immune system and microenvironment have not been effective at predicting safety and efficacy of immunomodulating cancer drugs.

Taconic Biosciences showcases its novel animal models at AACR 2017

Pharmatest Services, Ltd. and Taconic Biosciences, both leaders in the development of predictive animal models, presented a poster at AACR 2017 showing the proliferation of human breast cancer cells in the bone injection site of humanized mice. The observed tumor growth, bone remodeling, and infiltration by human immune cells were similar to that seen in human breast cancer patients suffering from bone metastases.

Validation of this mouse model would be a very promising development for preclinical testing of immuno-oncology drug candidates and combination therapies.

 

Mass spectrometry imaging to characterize tumor microenvironment: Imabiotech

Imabiotech’s novel mass spectrometry imaging technology provides better toxicity and efficacy assessments in a number of therapeutic research areas, including immuno-oncology.

One challenge facing the Cancer Moonshot Initiative is that novel technologies are required to address tumor heterogeneity (at the cellular and molecular levels). Thus, the Blue Ribbon Panel called out multiplexed, quantitative imaging as a promising way to connect function with localization.

Imabiotech Corporation is a widely-published expert in the emerging field of mass spectrometry imaging, which is a promising technology to address tumor heterogeneity. Their poster and exhibit at AACR 2017 showcased how mass spectrometry imaging could be used to quantitatively characterize responses to immunotherapy in the tumor microenvironment, with spatial resolution.


Toward 3D patient-derived models of breast cancer, lung cancer, and glioblastoma: KIYATEC, Inc.

Another of the most challenging aspects of oncology is the fact that each patient has a different response to a particular therapy. Recognizing this, the Moonshot Initiative’s recommendations included a call to establish patient-derived test models, such as organoids and xenografts, in which candidate drugs could be tested before treatment.

KIYATEC presents 3D cell-based models for drug response profiling at AACR 2017

KIYATEC, whose expertise lies in generating and using 3D cell-based models for drug response profiling, presented their work on breast cancer, lung cancer, and glioblastoma multiforme (GBM), in three posters at AACR 2017.

One study addressed the challenges facing small cell lung cancer (SCLC) patients, for whom surgical resection is rarely feasible. Therefore, patient-derived tissue is difficult to obtain. KIYATEC was able to isolate functional cancer stem cells and circulating tumor cells, label-free, from SCLC patients, with the aim of developing 3D microtumors from these cells.

KIYATEC also showed that 3D models of breast cancer, which incorporated multiple stromal cell types and immune cells, responded differently to immune checkpoint inhibitors than standard 2D cell culture models. Finally, KIYATEC tackled GBM, for which therapy is particularly confounded by intra-tumor and inter-patient heterogeneity. They developed an efficient method to develop patient-derived 3D models, which may enable more personalized treatments for GBM.

Interested in working with these service providers? Order services on Science Exchange today, or contact us about your project.

Koliber Biosciences Is Using Science Exchange To Develop Their Probiotic

January 20, 2016 | Posted by Team in Conferences, Events, Small Biotech Stories |

At the Blue Sky Bio Competition held during the SynBioBeta SF 2015 meeting, three finalists presented their ideas to the conference audience. They each hoped to win the prize resources in order to get the boost they needed to bring their ideas to fruition. Science Exchange sponsored this event, and presented the winners with $100,000 in credits to be used on the Science ExchEwa-Lisange platform. In the end, the audience decided to divide the winnings among the three finalists. Ewa Lis, founder and CEO of Koliber Biosciences and one of the winners, presented her ideas about probiotics and depression.

Ewa hopes to tackle the problem of depression. They propose to develop a probiotic strain that will produce a serotonin precursor of tryptophan directly in the gut. A probiotic supplement, especially if available over the counter, is more likely to be accepted by the large population of people that currently avoid medical treatment. It solves the problem of tryptophan degradation in the stomach and doesn’t require long treatment.

The market need for new depression treatments is clear. Depression affects 350 million people worldwide and results in $30 billion of economic loss. Two thirds of people suffering from depression do not seek medical treatment despite the existence of treatments. Moreover many failed treatments are due to patients stopping the medication themselves, often due to side effects.

Ewa and her team will use Science Exchange to develop probiotics that will ameliorate the effects of depression. To develop the strains they will use information from whole genome sequencing, RNA sequencing and analytical chemistry, services readily available via Science Exchange. Combined with their expertise in strain engineering and machine learning, they will be able to leverage the Science Exchange services to accelerate their research.

Science Exchange has many labs that can help Ewa and her team. For DNA sequencing, labs like Macrogen, Laragen, Quick Biology, Affiliated Genetics, ACGT and Applied Biological Materials can perform the work. For RNA sequencing, there are over 60 labs that can help Koliber Biosciences. In addition to these services, Science Exchange has labs that specifically focus on gut microbial community studies such as Second Genome. Lastly, Science Exchange offers many, many labs that perform standard studies such as amino acid analysis and compound synthesis. Science Exchange is the right resource to help Koliber Biosciences get started.

 

SEASR Conference for Core Facilities

May 28, 2013 | Posted by Team in Conferences |

seasr-logo-web

The Southeastern Association of Shared Resources (SEASR), a network of university core and shared resource facilities, will be hosting its launch conference this June, with support from the Science Exchange community.

The conference will be the first annual meeting hosted by the SEASR association, helping to provide a forum for core facility directors and scientists to discuss best practices and advances in technological applications. Science Exchange, in its continuing support for core facilities and the work they do to help scientists access high-end equipment at low-cost rates, is proud to be an initial corporate sponsor of the event, and will be hosting a workshop at the conference.

Read the rest of this entry »

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