New on Science Exchange: Focus on Spectrometry

October 4, 2017 | Posted by Team in Innovation Highlight, New Innovations |

Chandreyee Das, Ph.D. | Senior Content Manager, Science Exchange | www.scienceexchange.com

This installment of New on Science Exchange features spectrometry experts at CMP Scientific, Protypia, CovalX, Nightingale Health, and The Scripps Center for Metabolomics. Ready.. set … analyze.

Emass-II Ion Source CMP Scientific

CMP Scientific: Capillary electrophoresis – mass spectrometry (CE-MS) experts

Analytical researchers frustrated by the long separation times, high sample requirements, or low throughput of LC-MS have long been attracted to the advantages of CE-MS.

In 2015, the CE-MS technique was revolutionized — in that year, Brooklyn, New York-based CMP Scientific pioneered the EMASS-II CE-MS ion source, a novel interface between the capillary and the mass spectrometer’s electrospray emitter that conferred nanoflow sensitivity and high electrospray efficiency.

Since then, CMP Scientific has gained a proven track record for helping drug discovery and development companies develop CE-MS methods for pharmaceutical and biopharmaceutical analysis. Will your research program be the next to benefit from CE-MS technology?

Connect with the CMP Scientific team on Science Exchange.

 

The Scripps Center for Metabolomics: Respected mass spec core exposes the exposome

What are the biological effects of the exposome — i.e., the sum of all environmental toxicants, food contaminants and supplements, drugs, and antibiotics your body is exposed to daily?

Thanks to XCMS/METLIN, a software combined with a cloud-based database founded by the researchers at the Scripps Center for Mass Spectrometry and Metabolomics, investigations into the elusive exposome are now possible. On September 25, the lab published the results of their initial study — and we were very excited to have such a groundbreaking team join the Science Exchange network!

The facility serves its customers both at Scripps Research Institute as well as in the broader biotechnology community with its analytical expertise, for routine as well as specialty projects. They offer not only ESI, MALDI, and GC/MS of a wide range of samples and analytes, but also access to the world’s leading metabolomics/lipidomics platform.

 

Nightingale Health: Epidemiology-scale metabolomics, using NMR

Based in Helsinki, Finland, Nightingale Health has been transforming population health studies using its novel, NMR spectroscopy-based platform to detect multiple metabolites, across diverse pathways, in human plasma and serum. This fully automated biomarker quantification method can provide superior repeatability compared to mass spectrometry methods and is coupled with automated quality control.

Now available on Science Exchange, Nightingale Health’s services are accessible to researchers seeking novel biomarkers for large population studies of cardiovascular health, diabetes, and other aspects of metabolic syndrome.

 

Protypia: Advancing immunooncology through quantitative proteomics

The complexity of immune checkpoint signaling has led the field to the conclusion that there are more determinants to immunotherapeutic efficacy than PD-1 or PD-L1 expression alone. Vanderbilt University’s Daniel Liebler, President and Founder of Protypia, has used his team’s expertise in quantitative proteomics to show that differential glycation of checkpoint signaling proteins could affect tissue staining results as well as signaling protein function [abstract].

Visit the Protypia storefront to request a quote for your proteomics project — this team might just enable your next drug discovery breakthrough.

 

CovalX: High-Mass MALDI yields cost-effective info on epitopes

Founded in 2005, this global, fast-growing service provider established its prominence by developing a very differentiated technology  — fast, sensitive and accurate analysis of protein complexes by High-Mass MALDI mass spectrometry. Unfragmented and undigested, the protein complexes are detected intact using specially developed cross-linking reagents and high-mass detection system.

Combined with CovalX’s covalent crosslinking technology, this mass spectrometry method provides a method for epitope mapping that is faster and more cost-effective than many other conformational analysis techniques. For researchers analyzing protein biotherapeutics and biosimilars, it’s an attractive option.

 

Browse these and other new service providers on Science Exchange today!

 

Guest post: The rise of contractual conservatism – will it subvert sharing of scientific resources?

March 7, 2012 | Posted by Guest in Outsourcing Trends |

This is a guest post by Stephen Byers, Director of the Lombardi Shared Resources at the Lombardi Comprehensive Cancer Center, Georgetown University (full bio below). 

As director of shared resources at Georgetown University’s Lombardi Comprehensive Cancer Center and as Director of the Translation Technologies component of the Georgetown/Howard Univerity CTSA, my goal is to provide our researchers with the highest quality experimental resources, at the best possible price.  Sometimes that means adding in a new technology to our core facilities, sometimes it means reaching out to our CTSA network partners, sometimes it means negotiating with another institution altogether.   One reason I attend the Association of Biomolecular Resource Facilities (ABRF) annual conference is to keep up with cutting edge resources and explore what it makes sense for us expand or introduce as part of our core services and when it makes sense for us to find partners.

Different core facilities develop specializations, driven both by foresight as well as serendipity.   Georgetown, for example, has invested in an outstanding Metabolomics Shared Resource Program.  We’re finding that, in many cases, high throughput analysis of metabolites in blood or urine with LC-Mass Spectrometry is as good as genomic profiling at segregating outcomes in diseases… and a whole lot cheaper.  We can generate as many as 20-30,000 metabolite data points in an hour at $60/hr for 6 samples.  The real challenge for this field, as for much of post-genomic science, is the informatics that goes into analyzing all this data.  Under the guidance of our metabolomics gurus, Al Fornace and Amrita Cheema, and Medical Informatics Director Subha Madhavan, we are improving our informatics services and finding no shortage of investigators eager to take advantage of this technology.

Read the rest of this entry »

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