Take 5 – The Future of Now — How the Science of Today Shapes Tomorrow

March 21, 2018 | Posted by Team in Innovation Highlight |

by Gursatya “Guru” Singh, Director of Scientific Content, Science Exchange

Scientific research is advancing without pause; innovations are emerging at a breathtaking rate all over the world through the endeavors of diverse scientific disciplines. The future of scientific research is set on an unpredictable course teeming with both excitement and unease — whether AI-enabled tools will reshape drug discovery or if “patient-on-a-chip” technology will let future scientists create custom therapies for patients on the spot remains to be seen. Amidst the uncertainty, one thing remains clear: Science Exchange will be your fastest path to accessing new and emerging research tools, technologies, and services as the future continues to unfold.

A moment’s time is all you need to learn about the benefits of five promising technologies that may play an integral role in the near future. Sit back and Take 5! If something grabs your interest, click on the provided link to learn more about each service.

 

NanoMIPS

NanoMIPS

These novel affinity reagents, sometimes called “plastic antibodies,” have similar specificity to antibodies and can replace antibodies in in vitro applications, including sensing, imaging, purification, analysis, and diagnostics.

NanoMIPs are nanostructured Molecularly Imprinted Polymers, which typically contain a single binding site to a template molecule. NanoMIPs are prepared via a proprietary imprinting process that involves the self-assembly of binding monomers around a target template—these monomers are then polymerized to generate a “synthetic receptor” with high affinity and specificity to the template.

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FANA Antisense Oligonucleotide (FANA – ASO) TechnologyFANA Antisense Oligonucleotide (FANA – ASO) Technology

This next-generation chemical modification platform provides a superior alternative to CRISPR, siRNA, and shRNA approaches, and can be used to silence or regulate different RNA modalities.

Unlike conventional technologies, FANAs have high fidelity for the RNA target and highly reduced off-target effects (no RISC-associated off-target effects). These attributes represent a more potent, efficient, and cost-effective solution for RNA silencing and regulation.

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Intestinal Microbiota ScreeningI-SCREEN – Intestinal Microbiota Screening Platform

This translational intestinal screening multi-well platform simulates the human colonic microbiota conditions in vitro and helps identify the pharmacological compounds metabolized by intestinal microbiota.

The Netherlands Organization (TNO)’s i-screen service enables rapid identification of drugs that are susceptible to metabolism by intestinal microbiota. Additionally, it can be used to identify unknown metabolites transformed by intestinal microbiota.

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DigiWest™ Multiplex Protein ProfilingDigiWest™ Multiplex Protein Profiling Services

This service enables comprehensive profiling of up to 800 total and phosphoproteins from cell and tissue samples, using just 20–60 μg of protein.

Unlike other protein-profiling technologies, DigiWest allows in-depth analyses of cell signaling pathways on the level of phosphorylated proteins. As such, DigiWest adds significant value to biomarker identification, precision medicine, compound characterization, and mode-of-action studies.

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Visikol 3DScreen3DScreen™ High-Content Assay Development

This unique service is based on a patent-pending biological clearing agent called Visikol™ that penetrates tissue and renders it transparent without causing structural damage.

The assay has applications in the fields of toxicology, preclinical drug development, clinical diagnostics, basic research and plant biology, as tissues can be easily visualized in 3 dimensions.

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Lab Profile: uBiome, microbiome sequencing made easy

March 19, 2014 | Posted by Tess Mayall in Provider Spotlight |

Recently I talked with uBiome, a Science Exchange laboratory that specializes in microbiome sequencing. What makes them spectacular is more than just their sequencing services. It’s their unique perspective on science, the microbiome, and the cycle of research. There are tons of amazing facets to uBiome, but to name a couple:

  • They are the largest crowdfunded citizen science project to date – they raised more than $350,000 on indiegogo.
  • They have a fully automated, scalable robotic next-generation sequencing pipeline that can handle 10,000 samples as easily as 10 samples.

uBiome was founded by Jessica Richman and Zac Apte, who came together to start something different – a place where researchers can work with citizen scientists to create a game-changing dataset of microbial information.

According to Jessica, “We are excited about the process of collaborative citizen science around the microbiome. The idea is to involve the public, ask questions, and include the public in the researcher’s process.”

It’s this approach that helped them amass the largest dataset of human microbiome info. As a result, they can offer something unique to researchers, the chance to compare participants’ data to each other.

“If you’re studying anything, from heart disease to autism, we can sample and sequence your participants and compare them to our dataset. If researchers are sampling something that’s not one of our existing sites, we can still sequence anything they’re interested in – feet, noses, worms, animals, environmental samples, anything that has bacteria on it. We can run those through our pipeline and give data back about what’s in them,” said Jessica Richman.

They make the process as simple as possible for the researcher. They can be hands on and take care of sample collection, participant surveys, and sequencing. Or they can leave the details to the researchers and simply sequence the samples in their lab. In addition, researchers can compare their samples with groups of interest in the uBiome dataset.

uBiome is making is making microbiome sequencing easier than ever. Check out their services on Science Exchange.

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